Effect of Omega-3 Polyunsaturated Fatty Acids Intake on Eosinophil Airway Inflammation in University Athletes

Abstract

Background: Though athletes have a high risk of respiratory disorders, effective prevention has not yet to be identified. Omega-3 (n-3) polyunsaturated fatty acids (PUFA) have some practical anti-inflammatory effects in allergy, and therefore may reduce airway inflammation in athletes. This study aimed to assess whether n-3 PUFA intake affects airway inflammation in university athletes.

Methods: Twenty-three males were divided into three groups: 1) the eosinophilic airway inflammation group (I_PUFA group; fractional exhaled nitric oxide (FeNO ? 25 ppb, n = 10); 2) the non-eosinophilic airway inflammation group (N_PUFA group; FeNO < 25 ppb, exhaled carbon dioxide (eCO) ? 3.6 ppm, n = 5); and 3) the control group (FeNO < 25 ppb, eCO < 3.6 ppm, n = 8). Participants took supplements containing 260 mg of docosapentaenoic acid and 600 mg of eicosapentaenoic acid (EPA) daily for 3 weeks. Baseline measurements of FeNO, respiratory impedance, respiratory function, dietary intake (food frequency questionnaires), and blood tests were performed. FeNO and respiratory impedance were measured weekly, and the rest were measured after 3 weeks.

Results: There was a significant decrease in FeNO levels from baseline at 2 and 3 weeks in the I_PUFA group (54.7 8.5 ppb vs. 45.1 9.1 and 45.4 7.7 ppb; mean standard error (SE), P < 0.05). After 3 weeks, FeNO levels remained unchanged in the N_PUFA and control groups, and respiratory impedance and function remained unchanged in all groups. Blood EPA levels significantly increased in the I_PUFA and N_PUFA groups (I_PUFA, 27.7 16.9 vs. 52.1 12.3 g/mL; N_PUFA, 20.8 8.7 vs. 70.4 36.1 g/mL; mean standard deviation (SD), P < 0.05). No changes were observed in dietary intake over the 3 weeks.

Conclusions: n-3 PUFA supplementation for 3 weeks reduced airway inflammation in athletes with FeNO levels ? 25 ppb.

J Clin Med Res. 2022;14(11):466-473
doi: https://doi.org/10.14740/jocmr4825