Transformation of Low-Grade Mucinous Neoplasm of the Appendix With Pseudomyxoma Peritonei to High-Grade Sarcomatoid Carcinoma

Yu-Nung Chen, Jie-Jen Lee, Shih-Ping Cheng, Chung-Hsin Tsai


A 66-year-old man initially underwent appendectomy and cytoreductive surgery for a low-grade appendiceal mucinous neoplasm with pseudomyxoma peritonei. One and a half years later, multiple disseminated lesions developed in rectus abdominis muscle and peritoneal cavity. Biopsy showed histopathological transformation to sarcomatoid carcinoma. This case illustrates that evolution of low-grade pseudomyxoma peritonei to high-grade carcinoma truly develops in some patients. The development of this dedifferentiation appears associated with aggressive behavior and poor clinical outcome.

J Clin Med Res. 2015;7(7):571-574


Dedifferentiation; Pseudomyxoma peritonei; Recurrence

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