Recurrent Arterial and Venous Thromboemboli as Initial Presentation of Acute Promyelocytic Leukemia

Felix Trottier-Tellier, Madeleine Durand, Christophe Kolan, Robert Wistaff, Paul Van Nguyen, Mikhael Laskine


We report a case of a 52-year-old Caucasian woman diagnosed with a synchronic arterial and venous thrombosis as an initial presentation of an acute promyelocytic leukemia (APL). After the diagnosis, the patient was treated with all trans-retinoic acid and arsenic chemotherapy concomitant to systemic anticoagulation. This treatment regimen led to a complete remission and absence of relapse of the thrombosis or APL during the follow-up. To our knowledge, this presentation is the second case in the literature. We use this opportunity to emphasize the importance of performing a complete medical evaluation in cases of unusual thromboembolic events.

J Clin Med Res. 2014;6(5):388-391


Acute promyelocytic leukemia; All trans-retinoic acid and arsenic treatment; Arterial and venous thrombosis; Systemic anticoagulation

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