The Underlying Mechanisms for Olanzapine-induced Hypertriglyceridemia

Hiroki Adachi, Hidekatsu Yanai, Yuji Hirowatari


Olanzapine is an efficacious antipsychotic drug often used in the treatment for schizophrenia or bipolar disorder, however, sometimes induces metabolic disorders. We will introduce a patient with bipolar disorder, who has been treated by olanzapine and showed severe hypertriglyceridemia. As a result of measurements of parameters associated with lipid metabolism, very-low density lipoprotein was the most important lipoprotein for olanzapin-induced hypertriglyceridemia. The cessation of olanzapine significantly decreased high-sensitivity C-reactive protein and increased adiponectin, proposing that inflammation and reduced adiponectin level may be associated with olanzapin-induced hypertriglyceridemia.



Adiponectin; Hypertriglyceridemia; Inflammation; Olanzapine

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