The Association Between Reactive Oxygen Metabolites and Metabolic Syndrome in Asymptomatic Japanese Men

Abstract

Background: The association between the oxidative status and metabolic syndrome (MetS) should be studied in various populations with various oxidative stress-related markers. The aim of this cross-sectional study was to investigate the association between oxidative status, as assessed by the reactive oxygen metabolites (d-ROMs) test, and MetS in asymptomatic Japanese men, in relation to age.

Methods: The serum d-ROMs levels were measured in cardiovascular disease-free, non-smoking, non-medicated males (n = 140), who were divided into groups as follows: Group 1, < 60 years (n = 75, mean age 46 9 [SD] years), and Group 2, >= 60 years (n = 65, mean 68 6 years). The MetS was determined by the NCEP-ATP recommendations with minor modifications for a Japanese population.

Results: There was no significant difference in the d-ROMs levels between the subjects with and without MetS in Group 2 (>= 60 years), but the subjects with MetS (n = 38, 324 59 U. Curr.) exhibited significantly higher d-ROMs levels than those without MetS (n = 37, 290 49 U. Curr., P < 0.01) in Group 1 (< 60 years). These differences did not change even after adjustments for basic confounders.

Conclusions: These results suggest that oxidative status, as assessed by the d-ROMs, can be enhanced among asymptomatic younger, but not older, Japanese males with MetS. Further studies are required to establish the observed associations.

doi:10.4021/jocmr668w