Acute Promyelocytic Leukemia in a Patient With Chronic Continuous Type of Crohns Disease
Abstract
Chronic inflammation can induce leukemogenic mutations in hematopoietic stem cells (HSCs). We report a case of acute promyelocytic leukemia (APL) in a patient with chronic continuous type of Crohns disease. The patient had been diagnosed with Crohns disease at the age of 28 years and had received conventional treatments with biologics, but not azathioprine. At the age of 51, he was diagnosed with APL with ider(17). Long-term exposure to chronic continuous inflammation from Crohns disease might be a factor inducing genomic instability in HSCs, which lead to the subsequent development of APL. APL is a rare hematological manifestation that required attention in Crohns disease patients.
J Clin Med Res. 2022;14(3):136-141
doi: https://doi.org/10.14740/jocmr4675
Keywords
Acute promyelocytic leukemia; Crohn’s disease; Inflammatory bowel disease; Chronic inflammation; Hematopoietic stem cell; Myeloid neoplasm