Mechanism and Effect of Beta-Blockers on Pancreatic Adenocarcinoma: A Literature Review

Vandan D. Upadhyaya, Steven Douedi, Brandon Garcia, Jimmy Gonzalez, Ndausung Udongwo, Juanqin Wei, Qiang Nai, Arif Asif, Shuvendu Sen

Abstract


Pancreatic adenocarcinoma has a poor 5-year survival rate despite many advancements in pharmacotherapies. Studies have suggested the involvement of beta-adrenergic pathway in the progression of pancreatic adenocarcinoma. Animal experiments and retrospective trials have reported the use of beta-blockers as potential chemo-preventative agents. This review aims to discuss beta-adrenergic physiology as it relates to the progression of pancreatic adenocarcinoma and review outcomes on the use of beta-blockers for its treatment.




J Clin Med Res. 2020;12(12):753-757
doi: https://doi.org/10.14740/jocmr4387

Keywords


Beta-adrenergic pathway; Pancreatic adenocarcinoma; Beta-blockers; Cancer

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