How Can Galectin-3 as a Biomarker of Fibrosis Improve Atrial Fibrillation Diagnosis and Prognosis?

Maria Mariana Barros Melo da Silveira, Joao Victor Batista Cabral, Bruno de Melo Souza, Louis Hussein Patu Hazime, Sara Larissa de Melo Araujo, Amanda Tavares Xavier, Edivaldo Bezerra Mendes Filho, Luydson Richardson da Silva Vasconcelos, Dario Celestino Sobral Filho, Dinaldo Cavalcanti de Oliveira

Abstract


Galectin-3 (Gal-3) is a biomarker of fibrosis that has been associated with atrial remodeling. Acknowledging the presence of a biomarker in patients with atrial fibrillation (AF) can allow for a better clinical treatment. The aim of this study was to assess the association of Gal-3 with atrial fibrosis in patients with AF. This is a systematic review study. From the total number of studies analyzed, 12 demonstrated a relation between atrial fibrosis and Gal-3 in patients with AF and presented statistically significant association values. We conclude that Gal-3 is associated with atrial fibrosis in patients with AF in all types, as well as after the arrhythmia treatment by ablation.




J Clin Med Res. 2020;12(10):647-654
doi: https://doi.org/10.14740/jocmr4313

Keywords


Galectin-3; Atrial fibrosis; Atrial fibrillation; Clinical studies; Observational studies; Experimental studies

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