Isolated Adrenocorticotropic Hormone Deficiency and Severe Hypercalcemia After Destructive Thyroiditis in a Patient on Nivolumab Therapy With a Malignant Melanoma

Kohzo Takebayashi, Atsushi Ujiie, Mio Kubo, Sho Furukawa, Mototaka Yamauchi, Hiroyuki Shinozaki, Tatsuhiko Suzuki, Rika Naruse, Kenji Hara, Takafumi Tsuchiya, Toshihiko Inukai

Abstract


We describe a 58-year-old man with a malignant melanoma metastasis to the liver. After initiation of nivolumab therapy, he developed destructive thyroiditis and subsequently simultaneous isolated adrenocorticotropic hormone (ACTH) deficiency and severe hypercalcemia. Although isolated ACTH deficiency and hypercalcemia due to nivolumab therapy are both rare occurrences, these conditions can often cause a severe clinical course accompanied by a disturbance of consciousness. Therefore, clinicians should pay attention to these possible side effects of nivolumab if the patients have clinical symptoms, such as fatigue and a disturbance of consciousness.




J Clin Med Res. 2018;10(4):358-362
doi: https://doi.org/10.14740/jocmr3257w

Keywords


Nivolumab; Destructive thyroiditis; Isolated ACTH deficiency; Hypercalcemia

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