The Changes of HIF-1alpha and VEGF Expression After TACE in Patients With Hepatocellular Carcinoma

Lin Yang, Xu-Li Min, Juan Peng, Ke Yang, Lin Yang, Xiao-Ming Zhang

Abstract


As a common malignant tumor, hepatocellular carcinoma (HCC) has a high prevalence and is a serious threat to human health. The surgical resection rate of HCC is low, and the prognosis is poor. Although transarterial chemoembolization (TACE) is the main treatment for HCC patients who are not candidates for surgical resection, it is not considered a curative procedure. For HCC, poor TACE efficacy or TACE failure may be related to tumor angiogenesis of the residual disease. Among the many regulatory factors in tumor angiogenesis, hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) play vital roles in this process. In this paper, we conducted a review of the dynamic change and relevance of HIF-1alpha and VEGF levels after TACE of HCC patients.




J Clin Med Res. 2016;8(4):297-302
doi: http://dx.doi.org/10.14740/jocmr2496w


Keywords


Hepatocellular carcinoma; Transarterial chemoembolization; Vascular endothelial growth factor; Hypoxia-inducible factor-1α

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