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| Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access |
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Letter to the Editor
Volume 7, Number 6, June 2015, pages 499-500
Prevalence of Human T-Cell Leukemia Virus Type 1 Carrier in Japanese Pregnant Women in 2013
Shunji Suzukia, b, Masanobu Tanakaa, Hideo Matsudaa, Yuki Tsukaharaa, Yasushi Kuribayashia, Akihito Nakaia, Ryoichiro Miyazakia, Naoki Kamiyaa, Akihiko Sekizawaa, Nobuko Mizutania, Katsuyuki Kinoshitaa
aJapan Association of Obstetricians and Gynecologists, Japan
bCorresponding Author: Shunji Suzuki, Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, 5-11-12 Tateishi, Katsushika-ku, Tokyo 124-0012, Japan
Manuscript accepted for publication January 12, 2015
Short title: HTLV-1 Carrier in Japan
doi: http://dx.doi.org/10.14740/jocmr2097w
| To the Editor | ▴Top |
Since September 2010, in Japan serological screening for the detection of human T-cell leukemia virus type 1 (HTLV-1) antibodies can be performed for all women during pregnancy with the Japanese public funds for strategies for prevention of HTLV-1 vertical transmission, because Japan, especially Kyushu area, has been reported to be one of the areas of highest prevalence of HTLV-1 in the world [1, 2]. In our previous study [3], we examined the prevalence of HTLV-1 carrier in Japanese pregnant women according to the implement rate and results of HTLV-1 screening and confirmation tests of women who gave births in Japan in 2011. The total rates of positive HTLV-1 screening tests and positive western blot (WB) test in positive screening tests were 0.32% and 49.8%, respectively in 2011. Considering the response rate and the rate of implementation of WB test, the number of HTLV-1 carrier in Japanese pregnant women in 2011 was estimated to be 1,560 (0.15%). In addition, although the number of delivery in Kyushu area was only 14% of Japanese deliveries, 53% of HTLV-1 carrier of Japanese pregnant women was present in Kyushu area.
Recently, the migration of Japanese people from Kyushu area to the metropolitan areas has been thought to contribute to a significant decrease of HTLV-1 carriers in Kyushu area and an increase in Kanto (including Tokyo) area in Japan [1, 4]. To confirm this migration in Japanese pregnant women, on December 2014, we requested again 2,544 obstetrical facilities that are members of Japan Association of Obstetricians and Gynecologists (JAOG) to provide information of HTLV-1 tests in pregnant women who delivered at ≥ 22 weeks’ gestation in 2013. A total of 1,356 (53.3%) of 2,544 obstetrical facilities responded and information on a total of 538,167 women, accounting for approximately 54% of all deliveries that occurred in Japan during the study period (approximately 1,001,800 births) was provided.
In 2013, the total rates of positive HTLV-1 screening tests and positive WB test in positive screening tests were 0.35% and 50.8%, respectively. Considering the response rate and the rate of implementation of WB test, the number of HTLV-1 carrier in Japanese pregnant women in 2013 was estimated to be 1,780 (0.18%). Table 1 shows the difference in the estimated number of HTLV-1 carrier based on positive WB test by area in Japan between 2011 and 2013. The estimated number of HTLV-1 carrier in 2013 seemed to be more than that in 2011, especially in the northeast and southwest (Kyushu) areas. In addition, 51% of HTLV-1 carrier of Japanese pregnant women was present in Kyushu area, although the number of delivery in Kyushu area was only 13% of Japanese deliveries in 2013.
 Click to view | Table 1. Results of HTLV-1 Western Blot Tests and Estimated Number of Human T-Cell Leukemia Virus Type 1 Carrier in Pregnant Women Who Delivered at ≥ 22 Weeks’ Gestation in 2011 and 2013 by Area in Japan |
Although the migration of Japanese people from Kyushu area to the metropolitan areas has been supposed to contribute to a significant decrease of HTLV-1 carriers in Kyushu area, the estimated number of HTLV-1 carrier of pregnant women seemed to be increased in Kyushu area. In addition, the estimated rate of HTLV-1 carrier in pregnant women in Kyushu area was still significantly higher than that in the other areas (P < 0.01 by the Chi-square test). Therefore, there are still remaining problems concerning the locality for strategies for prevention of HTLV-1 vertical transmission in Japan.
Declaration of Interest
The authors report no conflicts of interest. The authors are responsible for the content and writing of the paper. This study was supported by the Japan Health, Labour and Welfare scientific research subsidies: “HTLV-1 mother-to-child transmission prevention research: cohort research of HTLV-1 antibody-positive pregnant women”.
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