Granulomas Formation in Lymph Nodes, Liver and Spleen in Adult-Onset Stills Disease: A Case Report

Abstract

Tissue granulomas formation in adult-onset Stills disease (AOSD) is extremely rare. We describe a case of AOSD associated with formation of granulomatous lesions in lymph nodes, liver and presumably spleen. The high dose steroid-dependent nature of our patients illness, characterized by disease relapses when methylprednisolone dose was reduced below 10 mg/d, was overwhelmed with institution of anakinra (100 mg/d). The histologic finding of granulomas formation in lymph nodes, liver or spleen should not deter the consideration of AOSD as a potential diagnosis in a compatible clinical context; however, other more common etiologies of tissue granulomas formation should be first excluded.




doi: http://dx.doi.org/10.4021/jocmr1281e