J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Short Communication

Volume 3, Number 6, December 2011, pages 319-324

The Association Between the Uncoupling Protein-1 Gene A-3826G Polymorphism and High-density Lipoprotein Cholesterol in A General Japanese Population: A Consideration of the Obesity Status

**Table 1.** The Clinical Characteristics of Subjects Based on the Genotypes of the Uncoupling Protein-1 Gene A-3826G Polymorphism in the Non-obese and Obese Groups
Genotype	Non-obese		Obese
BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; T-chol: total cholesterol;, HDL-C: high-density lipoprotein cholesterol; LHDLC: low high-density lipoprotein cholesterolemia; TG: triglycerides; HbA1c: hemoglobin A1c. The data are expressed as the means ( standard deviation, medians (interquartile range) or subject number (%). Differences in data between the genotype-based groups were examined by the unpaired t-test or χ²-test within each group of non-obese and obese subjects. The TG values were log-transformed because of their skewed distribution in the analysis. Significant level: *: P < 0.05.
Subject number (n)	147	45	-	75	27	-
Age (years)	66 ± 12	66 ± 13	0.98	63 ± 14	62 ± 15	0.72
Male (n)	67 (46%)	21 (47%)	0.90	30 (40%)	9 (33%)	0.55
Current smoker (n)	23 (16%)	8 (18%)	0.73	9 (12%)	3 (11%)	0.90
BMI (kg/m²)	22.2 ± 2.0	22.3 ± 1.9	0.64	27.1 ± 1.9	27.4 ± 2.3	0.48
SBP (mmHg)	139 ± 20	135 ± 19	0.26	139 ± 21	138 ± 17	0.92
DBP (mmHg)	77 ± 10	74 ± 10	0.08	78 ± 13	80 ± 13	0.52
T-chol (mmol/L)	4.85 ± 0.87	4.94 ± 1.13	0.69	4.86 ± 0.85	4.72 ± 0.97	0.48
HDL-C (mmol/L)	1.44 ± 0.38	1.43 ± 0.38	0.94	1.39 ± 0.36	1.20 ± 0.30	0.01*
LHDLC (n)	22 (15%)	6 (13%)	0.79	9 (13%)	10 (37%)	< 0.01*
TG (mmol/L)	0.98 (0.75-1.23)	0.98 (0.76-1.52)	0.24	1.05 (0.84-1.51)	1.15 (0.86-1.39)	0.86
HbA1c (%)	5.6 ± 1.3	5.6 ± 1.3	0.97	5.6 ± 0.7	5.5 ± 0.6	0.85

Table 1. The Clinical Characteristics of Subjects Based on the Genotypes of the Uncoupling Protein-1 Gene A-3826G Polymorphism in the Non-obese and Obese Groups

Genotype

Non-obese

Obese

A/A + A/G

G/G

P value

A/A + A/G

G/G

P value

BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; T-chol: total cholesterol;, HDL-C: high-density lipoprotein cholesterol; LHDLC: low high-density lipoprotein cholesterolemia; TG: triglycerides; HbA1c: hemoglobin A1c. The data are expressed as the means ( standard deviation, medians (interquartile range) or subject number (%). Differences in data between the genotype-based groups were examined by the unpaired t-test or χ²-test within each group of non-obese and obese subjects. The TG values were log-transformed because of their skewed distribution in the analysis. Significant level: *: P < 0.05.

Subject number (n)

147

Age (years)

66 ± 12

66 ± 13

0.98

63 ± 14

62 ± 15

0.72

Male (n)

67 (46%)

21 (47%)

0.90

30 (40%)

9 (33%)

0.55

Current smoker (n)

23 (16%)

8 (18%)

0.73

9 (12%)

3 (11%)

0.90

BMI (kg/m²)

22.2 ± 2.0

22.3 ± 1.9

0.64

27.1 ± 1.9

27.4 ± 2.3

0.48

SBP (mmHg)

139 ± 20

135 ± 19

0.26

139 ± 21

138 ± 17

0.92

DBP (mmHg)

77 ± 10

74 ± 10

0.08

78 ± 13

80 ± 13

0.52

T-chol (mmol/L)

4.85 ± 0.87

4.94 ± 1.13

0.69

4.86 ± 0.85

4.72 ± 0.97

0.48

HDL-C (mmol/L)

1.44 ± 0.38

1.43 ± 0.38

0.94

1.39 ± 0.36

1.20 ± 0.30

0.01*

LHDLC (n)

22 (15%)

6 (13%)

0.79

9 (13%)

10 (37%)

< 0.01*

TG (mmol/L)

0.98 (0.75-1.23)

0.98 (0.76-1.52)

0.24

1.05 (0.84-1.51)

1.15 (0.86-1.39)

0.86

HbA1c (%)

5.6 ± 1.3

0.97

5.6 ± 0.7

5.5 ± 0.6

0.85

**Table 2.** The Results of the Multivariate-adjusted Logistic Regression Analysis of Factors Associated With Low High-density Lipoprotein Cholesterolemia in the Non-obese and Obese Groups
Factor	Non-obese
OR: odds ratio; CI: confidence interval; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; T-chol: total cholesterol; HDL-C: high-density lipoprotein cholesterol; TG: triglycerides; HbA1c: hemoglobin A1c. All the listed factors, including the G/G genotype of the uncoupling protein-1 gene A-3826G polymorphism (reference: the A/A + A/G genotypes), were entered into the multivariate-adjusted logistic regression analysis models. Significant level: *: P < 0.05.
Age (years)	1.04 (0.98-1.09)	0.19	1.04 (0.98-1.11)	0.22
Gender (male)	3.05 (0.86-10.78)	0.08	0.95 (0.19-4.75)	0.95
Current smoking (presence)	1.72 (0.43-6.83)	0.44	6.51 (0.71-59.9)	0.1
BMI (kg/m²)	0.94 (0.70-1.27)	0.69	1.53 (1.05-2.21)	0.03*
SBP (mmHg)	0.98 (0.94-1.02)	0.32	0.94 (0.89-0.99)	0.03*
DBP (mmHg)	1.02 (0.94-1.10)	0.63	1.06 (0.98-1.16)	0.15
T-chol (mmol/L)	0.95 (0.93-0.97)	< 0.01*	0.95 (0.92-0.99)	< 0.01*
TG (mmol/L)	1.03 (1.02-1.05)	< 0.01*	1.02 (1.01-1.03)	< 0.01*
HbA1c (%)	1.14 (0.79-1.65)	0.49	1.67 (0.51-5.46)	0.4
G/G genotype (presence)	0.51 (0.13-1.96)	0.33	6.85 (1.65-28.49)	< 0.01*

Table 2. The Results of the Multivariate-adjusted Logistic Regression Analysis of Factors Associated With Low High-density Lipoprotein Cholesterolemia in the Non-obese and Obese Groups

Factor

Non-obese

Obese

OR (95% CI)

P value

OR (95% CI)

P value

OR: odds ratio; CI: confidence interval; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; T-chol: total cholesterol; HDL-C: high-density lipoprotein cholesterol; TG: triglycerides; HbA1c: hemoglobin A1c. All the listed factors, including the G/G genotype of the uncoupling protein-1 gene A-3826G polymorphism (reference: the A/A + A/G genotypes), were entered into the multivariate-adjusted logistic regression analysis models. Significant level: *: P < 0.05.

Age (years)

1.04 (0.98-1.09)

0.19

1.04 (0.98-1.11)

0.22

Gender (male)

3.05 (0.86-10.78)

0.08

0.95 (0.19-4.75)

0.95

Current smoking (presence)

1.72 (0.43-6.83)

0.44

6.51 (0.71-59.9)

0.1

BMI (kg/m²)

0.94 (0.70-1.27)

0.69

1.53 (1.05-2.21)

0.03*

SBP (mmHg)

0.98 (0.94-1.02)

0.32

0.94 (0.89-0.99)

0.03*

DBP (mmHg)

1.02 (0.94-1.10)

0.63

1.06 (0.98-1.16)

0.15

T-chol (mmol/L)

0.95 (0.93-0.97)

< 0.01*

0.95 (0.92-0.99)

< 0.01*

TG (mmol/L)

1.03 (1.02-1.05)

< 0.01*

1.02 (1.01-1.03)

< 0.01*

HbA1c (%)

1.14 (0.79-1.65)

0.49

1.67 (0.51-5.46)

0.4

G/G genotype (presence)

0.51 (0.13-1.96)

0.33

6.85 (1.65-28.49)

< 0.01*