Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
Journal website https://www.jocmr.org

Original Article

Volume 16, Number 4, April 2024, pages 164-169

Significance of Hypoalbuminemia in the Development of Thromboembolic Complications in Severe Cases of SARS-CoV-2 Coronavirus Infection

Figures

Figure 1.
Figure 1. Significance of blood plasma albumin in the groups under scrutiny. The TEC patients’ plasma albumin level was veritably higher than in the comparison group. Group I: with TECs, Group II: TEC-free. TECs: thromboembolic complications.
Figure 2.
Figure 2. Correlation matrix of relationships between plasma concentrations of albumin, inflammatory markers and D-dimer. CRP: C-reactive protein; IL-6: interleukin-6.
Figure 3.
Figure 3. ROC curve of the significance of albumin concentration in severe cases of SARS-CoV-2 coronavirus infection. ROC: receiver-operating characteristic; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2.

Tables

Table 1. Patients’ Clinical Profile
 
AttributeTECs groupTEC-free groupP-value
Me: median; TEC: thromboembolic complication.
Number of patients, n (%)127 (100%)1,507 (100%)-
Average age, Me (Q1 - Q3)75 (62.5 - 82.0)58 (47.0 - 68.0)< 0.001
Male patients, n (%)71 (55.9%)776 (51.49%)0.339
Arterial hypertension, n (%)113 (88.97%)884 (58.65%)< 0.001
Ischemic heart disease, n (%)116 (91.33%)447 (29.66%)< 0.001
Chronic heart failure, n (%)53 (41.73%)148 (9.82%)< 0.001
Chronic kidney disease, n (%)105 (82.67%)981 (65.09%)< 0.001
Type 2 diabetes mellitus, n (%)54 (42.51%)238 (15.79%)< 0.001
Obesity, n (%)23 (18.11%)175 (11.61%)0.031
Average pulmonary involvement, Me (Q1 - Q3)55% (37.5 - 67.5)37.5% (25.0 - 47.5)< 0.001
Oxygen saturation on room air (SpO2), Me (Q1 - Q3)92.0% (88.0 - 95.0)95.0% (93.0 - 97.0)< 0.001

 

Table 2. Plasma Concentrations of Inflammation Markers in the Groups Under Scrutiny
 
IndicatorTECs groupTEC-free groupP-value
IL-6: interleukin-6; TEC: thromboembolic complication.
C-reactive protein, mg/L129 (60.1 - 211)41.0 (12.2 - 97.6)< 0.001
Ferritin, µg/L363 (207 - 516)314 (186 - 516)0.481
IL-6, pg/mL176 (52.9 - 471)39.4 (11.0 - 107)< 0.001
Fibrinogen, g/L6.95 (4.98 - 9.13)5.70 (4.98 - 9.13)0.003