J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website https://www.jocmr.org

Short Communication

Volume 15, Number 1, January 2023, pages 51-57

Reduced Time to Procedure for Gastrointestinal Bleeding After Warfarin Reversal With Four-Factor Complex Concentrate as Compared to Plasma

Figure 1. Intensive care unit lengths of stay (in days) in the plasma and 4F-PCC groups. In each boxplot, the bold line is the median, the other lines are the quartiles of the data with outlier values displayed individually as points. 4F-PCC: four-factor prothrombin complex concentrate.

Figure 2. Emergency department lengths of stay (in h) in the plasma and 4F-PCC groups. In each boxplot, the bold line is the median, the other lines are the quartiles of the data with outlier values displayed individually as points. 4F-PCC: four-factor prothrombin complex concentrate.

Figure 3. Time from admission to GI procedure (in h) in the plasma and 4F-PCC groups. In each boxplot, the bold line is the median, the other lines are the quartiles of the data with outlier values displayed individually as points. GI: gastrointestinal; 4F-PCC: four-factor prothrombin complex concentrate.

**Table 1.** Laboratory Data and Patient Characteristics at Time of Admission
Characteristics and laboratory data	Unit	4F-PCC, mean ± SD (N), N = 49	Plasma, mean ± SD (N), N = 63	P-value
Data are shown in mean ± SD. SD: standard deviation; 4F-PCC: four-factor prothrombin complex concentrate; aPTT: activated partial thromboplastin time; PT: prothrombin time; INR: international normalized ratio; AST: aspartate aminotransferase; ALT: alanine aminotransferase.
Age	years	71.1 ± 14.2 (49)	72.1 ± 14.6 (49)	0.699
Sex	M	26	39	0.885
	F	23	24
Hemoglobin	g/dL	7.94 ± 2.61 (48)	9.16 ± 3.1 (63)	0.028
Hematocrit	%	22.37 ± 9.56 (15)	39.03 ± 53.53 (29)	0.027
Platelet count	× 10³/µL	277 ± 130.02 (48)	226.77 ± 83.16 (61)	0.043
aPTT	s	48.97 ± 32.3 (37)	43.95 ± 15.99 (40)	0.565
PT	s	58.56 ± 45.73 (45)	44.62 ± 28.78 (60)	0.110
INR on admission	-	5.77 ± 5.94 (45)	4.01 ± 2.53 (59)	0.080
INR after reversal	-	1.27 ± 0.21 (34)	1.95 ± 0.69 (35)	< 0.0001
AST	U/L	35.29 ± 34.21 (41)	32.05 ± 18.67 (38)	0.372
ALT	U/L	31.9 ± 17.54 (41)	32.95 ± 24.56 (40)	0.374
ED length of stay	h	11.59 ± 16.16 (49)	13.46 ± 17.38 (63)	0.286
ICU length of stay	days	3.39 ± 4.69 (23)	4.01 ± 2.71 (13)	0.123
Hospital length of stay	days	5.61 ± 4.43 (49)	5.53 ± 4.32 (62)	0.955
Time from admission to GI procedure	h	29.37 ± 30.65 (36)	34.2 ± 19.69 (52)	0.011
Comorbidities	Average of events	4.2	2.7	< 0.001

Table 1. Laboratory Data and Patient Characteristics at Time of Admission

Characteristics and laboratory data

Unit

4F-PCC, mean ± SD (N), N = 49

Plasma, mean ± SD (N), N = 63

P-value

Data are shown in mean ± SD. SD: standard deviation; 4F-PCC: four-factor prothrombin complex concentrate; aPTT: activated partial thromboplastin time; PT: prothrombin time; INR: international normalized ratio; AST: aspartate aminotransferase; ALT: alanine aminotransferase.

Age

years

71.1 ± 14.2 (49)

72.1 ± 14.6 (49)

0.699

Sex

0.885

Hemoglobin

g/dL

7.94 ± 2.61 (48)

9.16 ± 3.1 (63)

0.028

Hematocrit

22.37 ± 9.56 (15)

39.03 ± 53.53 (29)

0.027

Platelet count

× 10³/µL

277 ± 130.02 (48)

226.77 ± 83.16 (61)

0.043

aPTT

48.97 ± 32.3 (37)

43.95 ± 15.99 (40)

0.565

58.56 ± 45.73 (45)

44.62 ± 28.78 (60)

0.110

INR on admission

5.77 ± 5.94 (45)

4.01 ± 2.53 (59)

0.080

INR after reversal

1.27 ± 0.21 (34)

1.95 ± 0.69 (35)

< 0.0001

AST

U/L

35.29 ± 34.21 (41)

32.05 ± 18.67 (38)

0.372

ALT

U/L

31.9 ± 17.54 (41)

32.95 ± 24.56 (40)

0.374

ED length of stay

11.59 ± 16.16 (49)

13.46 ± 17.38 (63)

0.286

ICU length of stay

days

3.39 ± 4.69 (23)

4.01 ± 2.71 (13)

0.123

Hospital length of stay

days

5.61 ± 4.43 (49)

5.53 ± 4.32 (62)

0.955

Time from admission to GI procedure

29.37 ± 30.65 (36)

34.2 ± 19.69 (52)

0.011

Comorbidities

Average of events

4.2

2.7

< 0.001