J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website https://www.jocmr.org

Original Article

Volume 14, Number 10, October 2022, pages 409-415

Clinical Utility of the Geriatric Nutritional Risk Index Before Surgical Intervention for Epithelial Ovarian Cancer Patients: A Retrospective Study

Figure 2. Yearly transition of median ages of epithelial ovarian cancer patients who underwent surgical intervention.

Figure 3. Survival curve of epithelial ovarian cancer patients stratified by histological type of cancer. OS: overall survival.

**Table 1.** Patient Characteristics Categorized According to GNRI
Variables	Low GNRI group (n = 33)	High GNRI group (n = 42)	P value
BMI: body mass index; CA-125: cancer antigen-125; FIGO: International Federation of Gynecology and Obstetrics; GNRI: geriatric nutritional risk index.
Median age in years (range)	60.0 (26 - 87)	58.5 (30 - 86)	0.478
BMI (kg/m²)			0.0113
< 22	24	18
≥ 22	9	24
Albumin (g/dL)			< 0.01
< 3.5	19	4
≥ 3.5	14	38
Disease stage (FIGO classification)			0.166
I, II	11	21
III, IV	22	21
Ascites			0.626
+	1	3
-	32	39
Residual tumor			0.0217
Complete, optimal	13	28
Suboptimal	20	14
Fibrinogen (mg/dL)	463 (236 - 808)	355 (190 - 722)	< 0.05
CA-125 (U/mL)			1.00
< 35	5	6
≥ 35	28	34
Histological type			0.41
Serous adenocarcinoma	9	14
Mucus adenocarcinoma	3	5
Endometrium adenocarcinoma	7	14
Clear cell adenocarcinoma	10	7
Others	4	2

Table 1. Patient Characteristics Categorized According to GNRI

Variables

Low GNRI group (n = 33)

High GNRI group (n = 42)

P value

BMI: body mass index; CA-125: cancer antigen-125; FIGO: International Federation of Gynecology and Obstetrics; GNRI: geriatric nutritional risk index.

Median age in years (range)

60.0 (26 - 87)

58.5 (30 - 86)

0.478

BMI (kg/m²)

0.0113

< 22

≥ 22

Albumin (g/dL)

< 0.01

< 3.5

≥ 3.5

Disease stage (FIGO classification)

0.166

I, II

III, IV

Ascites

0.626

Residual tumor

0.0217

Complete, optimal

Suboptimal

Fibrinogen (mg/dL)

463 (236 - 808)

355 (190 - 722)

< 0.05

CA-125 (U/mL)

1.00

< 35

≥ 35

Histological type

0.41

Serous adenocarcinoma

Mucus adenocarcinoma

Endometrium adenocarcinoma

Clear cell adenocarcinoma

Others

**Table 2.** Univariate and Multivariate Analysis of Risk Factors Associated With Overall Survival of Epithelial Ovarian Cancers
	HR (95% CI)	P value	HR (95% CI)	P value
BMI: body mass index; CA: cancer antigen; FIGO: International Federation of Gynecology and Obstetrics; GNRI: geriatric nutritional risk index; HR: hazard ratio; CI: confidence interval.
Age ≥ 60 (years)	0.92 (0.518 - 1.64)	0.777
Albumin < 3.5 (g/dL)	2.04 (1.14 - 3.68)	0.0171	1.26 (0.651 - 2.44)	0.492
BMI < 22 (kg/m²)	1.04 (0.578 - 1.86)	0.904
Ascites +	1.03 (0.307 - 3.47)	0.960
CA-125 ≥ 35 (U/L)	2.00 (0.840 - 4.75)	0.117
GNRI < 97.3	2.40 (1.33 - 4.31)	< 0.01	1.93 (1.01 - 3.70)	0.0481
Histological subtype	1.08 (0.855 - 1.37)	0.513
Residual tumor ≥ optimal	2.40 (1.33 - 4.31)	< 0.01	1.84 (0.910 - 3.70)	0.09
FIGO classification ≥ stage III	1.72 (0.939 - 3.15)	0.0789

Table 2. Univariate and Multivariate Analysis of Risk Factors Associated With Overall Survival of Epithelial Ovarian Cancers

HR (95% CI)

P value

HR (95% CI)

P value

BMI: body mass index; CA: cancer antigen; FIGO: International Federation of Gynecology and Obstetrics; GNRI: geriatric nutritional risk index; HR: hazard ratio; CI: confidence interval.

Age ≥ 60 (years)

0.92 (0.518 - 1.64)

0.777

Albumin < 3.5 (g/dL)

2.04 (1.14 - 3.68)

0.0171

1.26 (0.651 - 2.44)

0.492

BMI < 22 (kg/m²)

1.04 (0.578 - 1.86)

0.904

Ascites +

1.03 (0.307 - 3.47)

0.960

CA-125 ≥ 35 (U/L)

2.00 (0.840 - 4.75)

0.117

GNRI < 97.3

2.40 (1.33 - 4.31)

< 0.01

1.93 (1.01 - 3.70)

0.0481

Histological subtype

1.08 (0.855 - 1.37)

0.513

Residual tumor ≥ optimal

2.40 (1.33 - 4.31)

< 0.01

1.84 (0.910 - 3.70)

0.09

FIGO classification ≥ stage III

1.72 (0.939 - 3.15)

0.0789