J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 3, Number 1, February 2011, pages 30-35

Early Maternal Serum β-human Chorionic Gonadotropin Measurements After ICSI in the Prediction of Long-term Pregnancy Outcomes: A Retrospective Cohort Analysis

Figure 1.. β-hCG cut-off levels on receiver operating characteristic (ROC) curve that best discriminated between pregnancy outcomes.

**Table 1.** Patient Demographics and Cycle Characteristics Between Pregnancies That Reached Different Stages of Pregnancy
	Live-birth	Ongoing Pregnancy	Late Miscarriage	Ectopic Pregnancy	Early Miscarriage
Age	29.54 ± 5.05	29.61 ± 4.91	29.69 ± 5.29	30.4 ± 1.67	30.8 ± 4.83
Infertility duration	7.9 ± 3.97	8.34 ± 4.21	7.85 ± 4.43	10.4 ± 3.13	8.2 ± 5.23
No. of ampoules	51.59 ± 256.71	46.4 ± 230.91	27.87 ± 7.62	23 ± 7.42	29.71 ± 12.27
Days of stimulation	9.78 ± 1.86	9.78 ± 1.8	10.15 ± 2.92	9.2 ± 1.92	9.87 ± 1.73
No. of oocytes retrieved	12.48 ± 7.52	12.13 ± 7.33	13.25 ± 9.89	12 ± 6.44	11.8 ± 7.32
No. of MII	10.04 ± 6.47	9.76 ± 6.28	10.79 ± 8	10.6 ± 6.23	10.33 ± 6.77
Injected	10.12 ± 6.41	9.85 ± 6.22	10.71 ± 7.22	10.6 ± 6.23	10.33 ± 6.77
Fertilized	7.04 ± 4.51	6.78 ± 4.45	7.03 ± 5.48	5.4 ± 4.72	7.73 ± 5.57
Good embryo G1	4.15 ± 3.4	4.01 ± 3.23	3.94 ± 3.75	3.6 ± 2.88	5.2 ± 5.73
Fair embryo G2	2.43 ± 2.19	2.37 ± 2.07	2.49 ± 2.45	2.4 ± 2.61	2.33 ± 1.68
Poor embryo G3, G4	1.22 ± 1.76	1.14 ± 1.66	1.29 ± 1.67	0 ± 0	0.6 ± 1.35
No. of ET	3.75 ± 0.81	3.74 ± 0.83	3.76 ± 0.83	3.2 ± 1.3	3.4 ± 1.06

Table 1. Patient Demographics and Cycle Characteristics Between Pregnancies That Reached Different Stages of Pregnancy

Live-birth

Ongoing Pregnancy

Late Miscarriage

Ectopic Pregnancy

Early Miscarriage

Age

29.54 ± 5.05

29.61 ± 4.91

29.69 ± 5.29

30.4 ± 1.67

30.8 ± 4.83

Infertility duration

7.9 ± 3.97

8.34 ± 4.21

7.85 ± 4.43

10.4 ± 3.13

8.2 ± 5.23

No. of ampoules

51.59 ± 256.71

46.4 ± 230.91

27.87 ± 7.62

23 ± 7.42

29.71 ± 12.27

Days of stimulation

9.78 ± 1.86

9.78 ± 1.8

10.15 ± 2.92

9.2 ± 1.92

9.87 ± 1.73

No. of oocytes retrieved

12.48 ± 7.52

12.13 ± 7.33

13.25 ± 9.89

12 ± 6.44

11.8 ± 7.32

No. of MII

10.04 ± 6.47

9.76 ± 6.28

10.79 ± 8

10.6 ± 6.23

10.33 ± 6.77

Injected

10.12 ± 6.41

9.85 ± 6.22

10.71 ± 7.22

10.6 ± 6.23

10.33 ± 6.77

Fertilized

7.04 ± 4.51

6.78 ± 4.45

7.03 ± 5.48

5.4 ± 4.72

7.73 ± 5.57

Good embryo G1

4.15 ± 3.4

4.01 ± 3.23

3.94 ± 3.75

3.6 ± 2.88

5.2 ± 5.73

Fair embryo G2

2.43 ± 2.19

2.37 ± 2.07

2.49 ± 2.45

2.4 ± 2.61

2.33 ± 1.68

Poor embryo G3, G4

1.22 ± 1.76

1.14 ± 1.66

1.29 ± 1.67

0 ± 0

0.6 ± 1.35

No. of ET

3.75 ± 0.81

3.74 ± 0.83

3.76 ± 0.83

3.2 ± 1.3

3.4 ± 1.06

**Table 2.** Early Day 14 β-hCG Levels Between Pregnancies That Reached Different Stages of Pregnancy
	Live-birth*	Ongoing Pregnancy*	Late Miscarriage	Ectopic Pregnancy*	Early Miscarriage*
*Statistically significant
Number of pregnancies	136	125	169	92	72	189	5	256	15	246
Mean SD	1070.02 ± 1505.79	686.6 ± 1269.69	1081.14 ± 1505.42	528.64 ± 1132.24	650.45 ± 1249.53	976.27 ± 1457.17	113.89 ± 65.42	901.48 ± 1417.7	82.21 ± 249.33	935.43 ± 1434.87
Significance	P = 0.0277	P < 0.0001	P = 0.0948	P = 0.0162	P < 0.0001

Table 2. Early Day 14 β-hCG Levels Between Pregnancies That Reached Different Stages of Pregnancy

Live-birth*

Ongoing Pregnancy*

Late Miscarriage

Ectopic Pregnancy*

Early Miscarriage*

Present

Absent

Present

Absent

Present

Absent

Present

Absent

Present

Absent

*Statistically significant

Number of pregnancies

136

125

169

189

256

246

Mean SD

1070.02 ± 1505.79

686.6 ± 1269.69

1081.14 ± 1505.42

528.64 ± 1132.24

650.45 ± 1249.53

976.27 ± 1457.17

113.89 ± 65.42

901.48 ± 1417.7

82.21 ± 249.33

935.43 ± 1434.87

Significance

P = 0.0277

P < 0.0001

P = 0.0948

P = 0.0162

P < 0.0001

**Table 3.** β-hCG Cut-off Levels on Receiver Operating Characteristic (ROC) Curve That Best Discriminated Between Pregnancy Outcomes
	Cut-off	Area Under ROC	Sensitivity	Specificity
Live-birth	315.65	58.14%	77.94%	61.60%
Ongoing pregnancy	297.23	62.92%	78.70%	75.00%
Late miscarriage	297.23	67.72%	69.44%	70.90%
Ectopic pregnancy	241.96	81.17%	100.00%	66.80%
Early miscarriage	76.15	91.19%	93.33%	89.84%

Table 3. β-hCG Cut-off Levels on Receiver Operating Characteristic (ROC) Curve That Best Discriminated Between Pregnancy Outcomes

Cut-off

Area Under ROC

Sensitivity

Specificity

Live-birth

315.65

58.14%

77.94%

61.60%

Ongoing pregnancy

297.23

62.92%

78.70%

75.00%

Late miscarriage

297.23

67.72%

69.44%

70.90%

Ectopic pregnancy

241.96

81.17%

100.00%

66.80%

Early miscarriage

76.15

91.19%

93.33%

89.84%