Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
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Letter to the Editor

Volume 14, Number 3, March 2022, pages 142-145

Potential Biomarkers Associated With the Nature of Uterine Benign Mesenchymal Tumors


Figure 1.
Figure 1. Intravenous leiomyomatosis. (a) Photograph obtained from a histopathological study of a tissue section shows leiomyoma with abundant blood vessels in dilated veins. (b) An enlarged image of the dotted rectangle area shown in (a).


Table 1. Differential Expressions of SMA, CAV1, CCNB, CCNE, LMP2, NT5DC2, CD133, and Ki-67 in Human Uterine Mesenchymal Tumors and Uterine LANT-Like Tumor
Mesenchymal tumor typesAge, yearsNProtein expressiona
aStaining score of expression of smooth muscle actin (SMA), caveolin 1 (CAV1), cyclin B (CCNB), cyclin E (CCNE), low molecular protein 2 (LMP2), 5’-nucleotidase domain containing 2 (NT5DC2) and Ki-67 from results of immunohistochemistry (IHC) experiments. aProtein expression: estimated protein expressions by immunoblot analysis, IHC and/or quantitative-polymerase chain reaction (RT-PCR). -/+: partially positive (5-10% of cells stained); Focal+: focal-positive (focal or sporadic staining with less than 5% of cells stained); ++: staining with 5% or more, less than 90% of cells stained; +++: diffuse-positive (homogeneous distribution with more than 90% of cells stained); -: negative (no stained cells). U.LANT-like tumor: uterine leiomyomatoid angiomatous neuroendocrine tumor-like tumor: LMP2 [10-12]; CCNE [10, 12]; CAV1 [13]; NT5DC2 [14]; CD133 [9]; Ki-67 [11, 12]. STUMP: smooth muscle tumor of uncertain malignant potential [15, 16]. CCNE, LMP2, and CAV1 are potential biomarkers for human uterine mesenchymal tumors. bLANT: leiomyomatoid angiomatous neuroendocrin tumor (LANT) is described as a dimorphic neurosecretory tumor with a leiomyomatous vascular component [17]. NA: no answer.
Normal30s - 80s74+++---+++---
Leiomyoma (LMA)30s - 80s40+++++-/+-/++++-/+-+/-
  Ordinally leiomyoma30+++++-/+-+++-/++/-
  Cellular leiomyoma10++++-/+-/+++-/++/-
STUMP40s - 60s12+++++-/+-/+-/+NA+/+++
Bizarre leiomyoma40s - 50s4++++-/++Focal++NA+
Intravenous LMA50s3++++++-NA+++
Benign metastasizing50s1+++++++-NANA++
Leiomyosarcoma30s - 80s54-/+++++++-/+++++++/+++
U.LANTb-like tumor40s1+++NA++-NANA-