J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website https://www.jocmr.org

Original Article

Volume 13, Number 3, March 2021, pages 170-176

Perioperative Antibiotic Prophylaxis: An Educative Intervention Significantly Increases Compliance

**Table 1.** Number of Patients per Operation and in Total, Before and After the Intervention
	Before intervention	After intervention
Laparoscopic cholecystectomy	37	32
Hernia repair	25	16
Thyroidectomy	4	2
Total	66	50

Table 1. Number of Patients per Operation and in Total, Before and After the Intervention

Before intervention

After intervention

Laparoscopic cholecystectomy

Hernia repair

Thyroidectomy

Total

**Table 2.** Patients’ Characteristics Before and After the Intervention
	Before intervention	After intervention	P value
Age (years), mean	58.15 ± 14.05	53.82 ± 17.82	0.1598
Sex
Male	39/66	30/50
Female	27/66	20/50	0.9213
Diabetes mellitus	7.6%	14%	0.2605
Allergy history	9.1%	2%	0.1388

Table 2. Patients’ Characteristics Before and After the Intervention

Before intervention

After intervention

P value

Age (years), mean

58.15 ± 14.05

53.82 ± 17.82

0.1598

Sex

Male

39/66

30/50

Female

27/66

20/50

0.9213

Diabetes mellitus

7.6%

14%

0.2605

Allergy history

9.1%

0.1388

**Table 3.** Compliance With the Dose of Perioperative Antibiotic Prophylaxis per Operation and in Total, Before and After The Intervention
	ASHP criteria	Before intervention	After intervention	P value
ASHP: American Society of Health-System Pharmacists; AP: antibiotic prophylaxis.
Hernia repair	One single dose, preoperatively	0%	68.8%	P < 0.005
Thyroidectomy	AP depending on prosthetic material	25%	50%	1
Laparoscopic cholecystectomy	One single dose, preoperatively	0%	53.1%	P < 0.005
All operations		1.5%	58%	P < 0.005

Table 3. Compliance With the Dose of Perioperative Antibiotic Prophylaxis per Operation and in Total, Before and After The Intervention

ASHP criteria

Before intervention

After intervention

P value

ASHP: American Society of Health-System Pharmacists; AP: antibiotic prophylaxis.

Hernia repair

One single dose, preoperatively

68.8%

P < 0.005

Thyroidectomy

AP depending on prosthetic material

25%

50%

Laparoscopic cholecystectomy

One single dose, preoperatively

53.1%

P < 0.005

All operations

1.5%

58%

P < 0.005

**Table 4.** Number of Doses of Antibiotics Before and After the Educational Intervention
	Before intervention	After intervention
Cefoxitin	269	132
Metronidazole	15	65
Ciprofloxacin	13	9
Amikacin	3	-
Cefuroxime	-	32

Table 4. Number of Doses of Antibiotics Before and After the Educational Intervention

Before intervention

After intervention

Cefoxitin

269

132

Metronidazole

Ciprofloxacin

Amikacin

Cefuroxime

**Table 5.** Compliance With the Timing of Administration per Operation and in Total, Before and After the Educational Intervention
	Before intervention	After intervention	P value
Hernia repair	57.14%	42.86%	0.61
Thyroidectomy	50%	50%	0.47
Laparoscopic cholecystectomy	50.88%	49.12%	0.32
All operations	52.44%	47.56%	0.13

Table 5. Compliance With the Timing of Administration per Operation and in Total, Before and After the Educational Intervention

Before intervention

After intervention

P value

Hernia repair

57.14%

42.86%

0.61

Thyroidectomy

50%

0.47

Laparoscopic cholecystectomy

50.88%

49.12%

0.32

All operations

52.44%

47.56%

0.13

**Table 6.** Median of Cost (€) per Operation and in Total, Before and After the Educational Intervention
	Before intervention	After intervention	P value
Hernia repair	15.08	3.77	< 0.001
Thyroidectomy	13.2	14.72	0.933
Laparoscopic cholecystectomy	15.08	3.77	0.0017
All operations	15.08	3.77	< 0.01

Table 6. Median of Cost (€) per Operation and in Total, Before and After the Educational Intervention

Before intervention

After intervention

P value

Hernia repair

15.08

3.77

< 0.001

Thyroidectomy

13.2

14.72

0.933

Laparoscopic cholecystectomy

15.08

3.77

0.0017

All operations

15.08

3.77

< 0.01

**Table 7.** Mean of Hospitalization Days per Operation and in Total, Before and After the Educational Intervention
	Before intervention	After intervention	P value
Hernia repair	5.2	4.81	0.291
Thyroidectomy	7.25	4	0.4
Laparoscopic cholecystectomy	5.11	4.77	0.304
All operations	6	4	0.046

Table 7. Mean of Hospitalization Days per Operation and in Total, Before and After the Educational Intervention

Before intervention

After intervention

P value

Hernia repair

5.2

4.81

0.291

Thyroidectomy

7.25

0.4

Laparoscopic cholecystectomy

5.11

4.77

0.304

All operations

0.046