Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
Journal website http://www.jocmr.org

Short Communication

Volume 2, Number 5, October 2010, pages 225-229

Mitochondrial DNA in Residual Leukemia Cells in Cerebrospinal Fluid in Children with Acute Lymphoblastic Leukemia

Figures

Figure 1.
Figure 1. Relationship of mtDNA copy numbers/cell and positive/negative-minimal disease/persistent or residual disease (MD/PRD) Status. A) Cerebrospinal fluid (CSF) status of Patients 1 - 4 demonstrating relationship of MD/PRD-positive (black bar) and MD/PRD-negative (white bar) status with mtDNA copy number/cell (Y-axis). B) Peripheral blood mononuclear cells (PBMC) status of Patients 5 - 4 demonstrating relationship of MD/PRD-positive (black bar) and MD/PRD-negative (white bar) status with mtDNA copy number/cell (Y-axis). mtDNA copy numbers/cell for control or non-malignant cells range from 40 - 99 copies/cell [8].
Figure 2.
Figure 2. Association of CSF mtDNA copy numbers/cell with positive/negative-minimal disease/persistent or residual disease (MD/PRD) status.

Table

Table 1. Subject Demographics and Clinical Characteristics with ALL
 
Age
(years)		GenderClinical Course and Characteristics
M: male; F: female; CNS: central nervous system; EOT: end of therapy
Patient 15MNo CNS disease; remission at EOT
Patient 27MNo CNS disease; remission at EOT
Patient 36FCNS disease at diagnosis; CNS relapse in Year 1; remission at EOT
Patient 47MCNS disease at diagnosis; CNS relapse in Year 1; remission at EOT
Patient 58MNo CNS disease; bone marrow relapse at 6 months; remission at EOT
Patient 66MNo CNS disease; bone marrow relapse at 8 months; remission at EOT