J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website https://www.jocmr.org

Original Article

Volume 12, Number 9, September 2020, pages 612-617

Serum Irisin Levels and Clinical Implication in Elderly Patients With Type 2 Diabetes Mellitus

Figure

Figure 1. Irisin level in serum and clinical parameters between T2DM group and control group. Comparisons of irisin (ng/mL), BMI (kg/m²), systolic and diastolic blood pressure (SBP and DBP, mm Hg), hemoglobin (HB, g/L), alanine aminotransferase (ALT) and aspartate aminotransferase (AST, U/L) between groups. T2DM group: n = 71, and control group: n = 71. BMI: body mass index; T2DM: type 2 diabetes mellitus.

Tables

**Table 1.** Comparison of Irisin Level and Clinical Indices Between T2DM Group and Control Group
Groups	Diabetes	Control	P values
T2DM: type 2 diabetes mellitus; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; HB: hemoglobin; ALT: alanine aminotransferase; AST: aspartate aminotransferase.
Irisin (ng/mL)	703.4 ± 241.5	800.2 ± 275.6	0.03
BMI (kg/m²)	23.7 ± 3.5	21.2 ± 2.3	< 0.001
SBP (mm Hg)	145.4 ± 21.3	122.0 ± 10.9	< 0.001
DBP (mm Hg)	81.9 ± 10.7	74.1 ± 7.6	< 0.001
HB (g/L)	137.4 ± 11.2	135.3 ± 10.6	0.25
ALT (U/L)	24.2 ± 14.5	20.1 ± 11.0	0.06
AST (U/L)	22.1 ± 14.1	21.8 ± 6.9	0.86

**Table 2.** Comparison of Laboratory Test Parameters Between T2DM Group and Control Group
Groups	Diabetes	Control	P values
* P < 0.05. T2DM: type 2 diabetes mellitus; ALB: albumin; Cr: serum creatinine; BUN: blood urea nitrogen; FPG: fasting plasma glucose; CHOL: total cholesterol; TG: triglyceride.
ALB (g/L)	46.4 ± 2.4	46.0 ± 1.9	0.335
Cr (µmol/L)	66.9 ± 20.8	69.8 ± 16.5	0.37
BUN (mmol/L)	5.4 ± 1.3	5.3 ± 1.4	0.89
CHOL (mmol/L)	5.6 ± 1.0	5.3 ± 0.8	0.06
TG (mmol/L)	1.7 ± 1.3	1.0 ± 0.7	< 0.001*
FPG (mmol/L)	8.7 ± 5.5	5.3 ± 0.5	< 0.001*

**Table 3.** Logistic Regression Analysis of Influencing Factors of Diabetes Mellitus
Influencing factors	β	sx	Waldχ²	P value	OR (95% CI)
* P < 0.05. SBP: systolic blood pressure; FPG: fasting plasma glucose; OR: odds ratio; 95% CI: 95% confidence interval.
Irisin	-0.003	0.001	5.855	0.016	0.997 (0.994 - 0.999)
SBP	0.115	0.027	17.711	< 0.001*	1.122 (1.063 - 1.183)
FPG	1.783	0.437	16.633	< 0.001*	5.950 (2.525 - 14.020)