| Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc |
| Journal website http://www.jocmr.org |
Original Article
Volume 12, Number 8, August 2020, pages 492-498
A Study of Artificial Sweeteners and Thyroid Cancer Risk
Tables
| Beverages, one can (12 fl. oz or 355 mL) | Ingredients in beverages | Equivalent packets of various ingredients | Total packets of artificial sweeteners in one can | Grams (packets) in 1 L of a beverage |
|---|---|---|---|---|
| Diet Coke | 125 mg aspartame | 3.125 packets | 3.125 packets | 8.8 g (8.8 packets) |
| Diet Coke, caffeine | 125 mg aspartame | 3.125 packets | 3.125 packets | 8.8 g (8.8 packets) |
| Diet Coke with Splenda | 30 mg acesulfame K + 40 mg of sucralose | 0.77 packets + 3.07 packets | 3.8 packets | 10.7 g (10.7 packets) |
| Coke Zero | 58 mg aspartame + 31 mg acesulfame K | 1.45 packets + 0.8 packets | 2.25 packets | 6.34 g (6.34 packets) |
| Diet Pepsi | 118 mg aspartame | 2.95 packets | 2.95 packets | 8.3 g (8.3 packets) |
| Caffeine-free Diet Pepsi | 118 mg aspartame | 2.95 packets | 2.95 packets | 8.3 g (8.3 packets) |
| Diet Pepsi Jazz | 83 mg aspartame + 21mg acesulfame K | 2.075 packets + 0.538 packets | 2.16 packets | 6.08 g (6.08 packets) |
| Pepsi One | 30 mg aspartame + 40 mg sucralose | 0.75 packets + 3.077 packets | 3.82 packets | 10.76 g (10.76 packets) |
| Diet Dr. Pepper | 123 mg aspartame | 3.075 packets | 3.075 packets | 8.66 g (8.66 packets) |
| Diet Mountain Dew | 57 mg aspartame + 18 mg acesulfame K + 18 mg sucralose | 1.425 packets + 0.461 packets + 1.384 packets | 3.27 packets | 9.21 g (9.21 packets) |
| Sprite Zero | 50 mg aspartame + 34 mg acesulfame K | 1.25 packets + 0.871 packets | 2.12 packets | 5.97 g (5.97 packets) |
| Fresca | 50 mg aspartame + 34 mg acesulfame K | 1.25 packets + 0.871 packets | 2.12 packets | 5.97 g (5.97 packets) |
| Tab | 64 mg saccharin + 19 mg aspartame | 3.2 packets + 0.475 packets | 3.67 packets | 10.33 g (10.33 packets) |
| Differentiated thyroid carcinoma (n = 50) | Benign thyroid nodule (n = 50) | P value | |
|---|---|---|---|
| BMI: body mass index. | |||
| Mean age | 52.4 ± 11.09 | 54.6 ± 12.45 | 0.648 |
| Sex | 0.348 | ||
| Male | 10 | 14 | |
| Female | 40 | 36 | |
| BMI | 0.439 | ||
| Underweight/normal | 16 | 11 | |
| Overweight | 24 | 30 | |
| Obese | 10 | 9 | |
| Artificial sweetener consumption | 36 | 12 | < 0.00001 |
| Average amount | 4 packets | 2 packets | |
| Family history of thyroid cancer | 3 | 1 | 0.307 |
| Alcohol intake ≥ 2 drinks/day | 4 | 6 | 0.504 |
| Irradiation in the childhood | 1 | 0 | 0.509 |