Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
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Case Report

Volume 12, Number 7, July 2020, pages 454-457

First Reported Use of Highly Adsorptive Hemofilter in Critically Ill COVID-19 Patients in the USA


Figure 1.
Figure 1. Cross-section of the oXiris filter. The first layer is composed of a polyacrylonitrile copolymer made up of acrylonitrile and methallylsulfonate. The negative charge of the sulfonate helps in adsorbing the cytokines. The second layer is composed of positively charged polyethyleneimine, which adsorbs the endotoxins. The third layer is pregrafted with heparin conferring antithrombogenic property.


Table 1. Laboratory Data
LabsReference range with unitsPatient 1Patient 2Patient 3
Day 1Day 2Day 3Day 1Day 2Day 3Day 1Day 2Day 3
WBC: white blood cells; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; IL-6: interleukin-6; SOFA: sequential organ failure assessment; N/A: not available.
WBC4.5 - 11.0 × 103/mm33.
ESR0 - 26.0 mm/h3539281576N/AN/AN/A
CRP0 - 0.5 mg/dL15.04616.14018.6045.4522.6712.2419.6554.0232.071
D-dimer0 - 230 ng/mL2,0402,9552,0159,0183,0999571,2311,1151,876
IL-6< 1.8 pg/mL64.636.590.6> 400> 400> 4007.79.83.5
Ferritin22 - 322 ng/mL2,964N/A2,2429881,260.41,213.9148.4163.3198.1
SOFA score1110109108333