J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Case Report

Volume 12, Number 7, July 2020, pages 454-457

First Reported Use of Highly Adsorptive Hemofilter in Critically Ill COVID-19 Patients in the USA

Figure

Figure 1. Cross-section of the oXiris filter. The first layer is composed of a polyacrylonitrile copolymer made up of acrylonitrile and methallylsulfonate. The negative charge of the sulfonate helps in adsorbing the cytokines. The second layer is composed of positively charged polyethyleneimine, which adsorbs the endotoxins. The third layer is pregrafted with heparin conferring antithrombogenic property.

Table

**Table 1.** Laboratory Data
Labs	Reference range with units	Patient 1			Patient 2			Patient 3
Labs	Reference range with units	Day 1	Day 2	Day 3	Day 1	Day 2	Day 3	Day 1	Day 2	Day 3
WBC: white blood cells; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; IL-6: interleukin-6; SOFA: sequential organ failure assessment; N/A: not available.
WBC	4.5 - 11.0 × 10³/mm³	3.2	4.0	5.7	8.4	8.8	9.0	12.5	15.0	15.6
ESR	0 - 26.0 mm/h	35	39	28	15	7	6	N/A	N/A	N/A
CRP	0 - 0.5 mg/dL	15.046	16.140	18.604	5.452	2.671	2.241	9.655	4.023	2.071
D-dimer	0 - 230 ng/mL	2,040	2,955	2,015	9,018	3,099	957	1,231	1,115	1,876
IL-6	< 1.8 pg/mL	64.6	36.5	90.6	> 400	> 400	> 400	7.7	9.8	3.5
Ferritin	22 - 322 ng/mL	2,964	N/A	2,242	988	1,260.4	1,213.9	148.4	163.3	198.1
SOFA score		11	10	10	9	10	8	3	3	3