Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
Journal website http://www.jocmr.org

Review

Volume 12, Number 7, July 2020, pages 393-403

The Impact of Cannabidiol on Psychiatric and Medical Conditions

Figures

Figure 1.
Figure 1. CBD chemical structure (source: PUBCHEM [9]). CBD: cannabidiol.
Figure 2.
Figure 2. Chemical structure of THC for comparison (source: PUBCHEM [9]). THC: tetrahydrocannabinol.

Tables

Table 1. CYP 450 Enzymes and Medication Interaction [23-36]
 
EnzymeMedication that interactsEffect
CBD: cannabidiol.
CYP3A4 substrateImmunosuppressants, antidepressants, opioids, statins, benzodiazepinesIncreases toxic effects/levels of substrate
CYP3A4 inhibitorKetoconazole, loperamide, nefazodone, cimetidine, verapamilIncreases level/toxicity of CBD
CYP3A4 inducerPhenytoin, topiramate, carbamazepine, rifampicin, efavirenz, pioglitazoneDecreases bioavailability of CBD
Reduces effect/level of CBD
CYP2C19 substrateProton pump inhibitor, antidepressants, antiepileptics, clopidogrel, propranolol, warfarin, cyclophosphamideIncreases toxic effects/level of substrate
CYP2C19 inhibitorCimetidine, proton pump inhibitors, fluvoxamine, clopidogrel, fluconazoleIncreases level/toxicity of CBD
CYP2C19 inducerPhenobarbital, phenytoin, St. John’s Wort, rifampicin, carbamazepineDecreases bioavailability of CBD
Reduces effect/level of CBD
CYP2C8/9Buprenorphine, montelukast, celecoxib, phenobarbital, phenytoin, warfarin, valsartanIncreases toxic effects/levels of substrate

 

Table 2. List of Toxic Effects From CBD Use [14, 42-85]
 
AnxietyDepressionSuicidal ideationPsychosisSedationAnaphylaxisRash
CBD: cannabidiol.
InsomniaNauseaDiarrheaVomitingDry mouthDizzinessInfections/immunosuppression