Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
Journal website http://www.jocmr.org

Original Article

Volume 12, Number 6, June 2020, pages 369-376


Purifying Selection in Human Immunodeficiency Virus-1 pol Gene in Perinatally Human Immunodeficiency Virus-1-Infected Children Harboring Discordant Immunological Response and Virological Nonresponse to Long-Term Antiretroviral Therapy

Figures

Figure 1.
Figure 1. Distribution of study children in virological failure (VF+) at inclusion and after the follow-up period, according to their immunological (CD4 T cell count) and virological (circulating viral load) responses to antiretroviral treatment. Results are expressed as mean ± standard deviation. I+: immunological responders; I-: immunological nonresponders; LTF: lost-to-follow up; CD4: cluster of differentiation 4.
Figure 2.
Figure 2. Estimates of codon-based evolutionary divergences between pairs of HIV-1 pol gene nucleotide sequences during a 39 months period of prospective follow-up of children and adolescents attending the Complexe Pediatrique of Bangui, Central African Republic. The genetic distances (expressed in percentage) of synonymous substitutions per 100 potential synonymous sites (dS) and of nonsynonymous substitutions per 100 potential nonsynonymous site (dN) accumulated during the follow-up period in circulating HIV-1 pol gene (a), as well as the (dN/dS) ω ratios (b) are shown for both (I+, VF+) and (I-, VF+) subgroups. For each distribution, the blank box represents the interquartile ranges, the horizontal bar corresponds to the median and the vertical bars and hats indicate the 10th and 90th percentiles. The dotted line identifies the neutral selection ratio (ω = 1). Comparisons used Wilcoxon’s test for paired data and Welch’s t-test between subgroups. P values are given above indentations.