J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 12, Number 3, March 2020, pages 157-164

Evaluation of the Activity of Neutrophils and Monocytes in Diabetic Patients With Sepsis, Can Surface Antigens HLA-DR and CD64 Be Useful as Prognostic Factors?

Figure 1. Cytometry flow analysis in a control patient (a), a patient with diabetes and sepsis that survived (b), and a patient that deceased (c), showing the expression of HLA-DR and CD64 on monocytes and neutrophils on day 7.

**Table 1.** Type of Infection
Infection	Number of patients
Respiratory	14 (27.45%)
Urinary tract	14 (27.45%)
Osteomyelitis	3 (5.88%)
Soft tissues	12 (23.52%)
Abdomen	8 (15.68%)

Table 1. Type of Infection

Infection

Number of patients

Respiratory

14 (27.45%)

Urinary tract

14 (27.45%)

Osteomyelitis

3 (5.88%)

Soft tissues

12 (23.52%)

Abdomen

8 (15.68%)

**Table 2.** Analysis of Predictors of Mortality Between Survivor and Non-Survivor Diabetics With Sepsis
Characteristics	Survivors	Non-survivors	P value
WBC: white blood cells; NLR: neutrophils to lymphocytes ratio; CD64M0: CD64 antigen on monocytes on day 0; CD64M3: CD64 antigen on monocytes on day 3; CD64M7: CD64 antigen on monocytes on day 7; CD64O0: CD64 antigen on neutrophils on day 0; CD64O3: CD64 antigen on neutrophils on day 3; CD64O7: CD64 antigen on neutrophils on day 7; HLA-DRM0: HLA-DR antigen on monocytes on day 0; HLA-DRM3: HLA-DR antigen on monocytes on day 3; HLA-DRM7: HLA-DR antigen on monocytes on day 7; HLA-DRO0: HLA-DR antigen on neutrophils on day 0; HLA-DRO3: HLA-DR antigen on neutrophils on day 3; HLA-DRO7: HLA-DR antigen on neutrophils on day 7; HLA-DR/CD64M0: HLA-DR/CD64 co-expression on monocytes on day 0; HLA-DR/CD64M3: HLA-DR/CD64 co-expression on monocytes on day 3; HLA-DR/CD64M7: HLA-DR/CD64 co-expression on monocytes on day 7; HLA-DR/CD64O0: HLA-DR/CD64 co-expression on neutrophils on day 0; HLA-DR/CD64O3: HLA-DR/CD64 co-expression on neutrophils on day 3; HLA-DR/CD64O7: HLA-DR/CD64 co-expression on neutrophils on day 7; phagoM0: percentage of phagocytosis in monocytes on day 0; phagoM7: percentage of phagocytosis in monocytes on day 7; phagoO0: percentage of phagocytosis in neutrophils on day 0; phagoO7: percentage of phagocytosis in neutrophils on day 7.
Age	71.03 ± 12.265	77.55 ± 9.015	0.068
WBC	15,438.25 ± 7,040.363	13,799.86 ± 6,172.514	0.663
NLR	9.838 ± 10.8683	12.552 ± 11.0357	0.292
SAPS II score	30.08 ± 10.159	34.64 ± 10.003	0.136
CRP	20.640 ± 13.0986	14.990 ± 10.4869	0.304
HbA1c	8.593 ± 2.6425	7.37 ± 1.17	0.308
CD64M0	19.38 ± 9.82	15.62 ± 5.22	0.262
CD64M3	12.88 ± 5.43	10.95 ± 2.83	0.267
CD64M7	14.40 ± 5.03	9.44 ± 4.42	0.023
CD64O0	11.58 ± 8.98	9.94 ± 3.99	0.900
CD64O3	7.83 ± 4.011	6.09 ± 1.49	0.290
CD64O7	11.03 ± 5.78	6.79 ± 4.24	0.062
HLA-DRM0	5.59 ± 2.74	5.09 ± 1.89	0.757
HLA-DRM3	4.54 ± 1.68	4.09 ± 0.96	0.679
HLA-DRM7	6.60 ± 2.32	4.73 ± 1.39	0.026
HLA-DRO0	5.23 ± 2.90	4.83 ± 2.16	0.464
HLA-DRO3	2.93 ± 0.82	3.22 ± 0.94	0.387
HLA-DRO7	7.19 ± 3.41	5.68 ± 2.91	0.189
HLA-DR/CD64M0	5.36 ± 2.66	4.85 ± 1.89	0.706
HLA-DR/CD64M3	4.35 ± 1.62	3.92 ± 0.97	0.747
HLA-DR/CD64M7	6.49 ± 2.26	4.38 ± 1.31	0.010
HLA-DR/CD64O0	3.36 ± 1.87	3.36 ± 2.00	0.973
HLA-DR/CD64O3	2.56 ± 1.42	2.24 ± 0.85	0.245
HLA-DR/CD64O7	4.21 ± 2.07	2.90 ± 0.82	0.143
PhagoM0	72.12 ± 19.06	73.99 ± 19.06	0.672
PhagoM7	70.30 ± 15.96	65.14 ± 23.94	0.709
PhagoO0	87.85 ± 11.66	88.39 ± 11.25	0.909
PhagoO7	88.52 ± 10.50	73.38 ± 26.96	0.083

Table 2. Analysis of Predictors of Mortality Between Survivor and Non-Survivor Diabetics With Sepsis

Characteristics

Survivors

Non-survivors

P value

WBC: white blood cells; NLR: neutrophils to lymphocytes ratio; CD64M0: CD64 antigen on monocytes on day 0; CD64M3: CD64 antigen on monocytes on day 3; CD64M7: CD64 antigen on monocytes on day 7; CD64O0: CD64 antigen on neutrophils on day 0; CD64O3: CD64 antigen on neutrophils on day 3; CD64O7: CD64 antigen on neutrophils on day 7; HLA-DRM0: HLA-DR antigen on monocytes on day 0; HLA-DRM3: HLA-DR antigen on monocytes on day 3; HLA-DRM7: HLA-DR antigen on monocytes on day 7; HLA-DRO0: HLA-DR antigen on neutrophils on day 0; HLA-DRO3: HLA-DR antigen on neutrophils on day 3; HLA-DRO7: HLA-DR antigen on neutrophils on day 7; HLA-DR/CD64M0: HLA-DR/CD64 co-expression on monocytes on day 0; HLA-DR/CD64M3: HLA-DR/CD64 co-expression on monocytes on day 3; HLA-DR/CD64M7: HLA-DR/CD64 co-expression on monocytes on day 7; HLA-DR/CD64O0: HLA-DR/CD64 co-expression on neutrophils on day 0; HLA-DR/CD64O3: HLA-DR/CD64 co-expression on neutrophils on day 3; HLA-DR/CD64O7: HLA-DR/CD64 co-expression on neutrophils on day 7; phagoM0: percentage of phagocytosis in monocytes on day 0; phagoM7: percentage of phagocytosis in monocytes on day 7; phagoO0: percentage of phagocytosis in neutrophils on day 0; phagoO7: percentage of phagocytosis in neutrophils on day 7.

Age

71.03 ± 12.265

77.55 ± 9.015

0.068

WBC

15,438.25 ± 7,040.363

13,799.86 ± 6,172.514

0.663

NLR

9.838 ± 10.8683

12.552 ± 11.0357

0.292

SAPS II score

30.08 ± 10.159

34.64 ± 10.003

0.136

CRP

20.640 ± 13.0986

14.990 ± 10.4869

0.304

HbA1c

8.593 ± 2.6425

7.37 ± 1.17

0.308

CD64M0

19.38 ± 9.82

15.62 ± 5.22

0.262

CD64M3

12.88 ± 5.43

10.95 ± 2.83

0.267

CD64M7

14.40 ± 5.03

9.44 ± 4.42

0.023

CD64O0

11.58 ± 8.98

9.94 ± 3.99

0.900

CD64O3

7.83 ± 4.011

6.09 ± 1.49

0.290

CD64O7

11.03 ± 5.78

6.79 ± 4.24

0.062

HLA-DRM0

5.59 ± 2.74

5.09 ± 1.89

0.757

HLA-DRM3

4.54 ± 1.68

4.09 ± 0.96

0.679

HLA-DRM7

6.60 ± 2.32

4.73 ± 1.39

0.026

HLA-DRO0

5.23 ± 2.90

4.83 ± 2.16

0.464

HLA-DRO3

2.93 ± 0.82

3.22 ± 0.94

0.387

HLA-DRO7

7.19 ± 3.41

5.68 ± 2.91

0.189

HLA-DR/CD64M0

5.36 ± 2.66

4.85 ± 1.89

0.706

HLA-DR/CD64M3

4.35 ± 1.62

3.92 ± 0.97

0.747

HLA-DR/CD64M7

6.49 ± 2.26

4.38 ± 1.31

0.010

HLA-DR/CD64O0

3.36 ± 1.87

3.36 ± 2.00

0.973

HLA-DR/CD64O3

2.56 ± 1.42

2.24 ± 0.85

0.245

HLA-DR/CD64O7

4.21 ± 2.07

2.90 ± 0.82

0.143

PhagoM0

72.12 ± 19.06

73.99 ± 19.06

0.672

PhagoM7

70.30 ± 15.96

65.14 ± 23.94

0.709

PhagoO0

87.85 ± 11.66

88.39 ± 11.25

0.909

PhagoO7

88.52 ± 10.50

73.38 ± 26.96

0.083

**Table 3.** Analysis of Characteristics in Septic Diabetic Patients With Excellent, Moderate and Inadequate Blood Glucose Control
Characteristics	HbA1c ≤ 7, HbA1c ≤ 53 mmol/mol	7 < HbA1c ≤ 8.5, 53 < HbA1c ≤ 69, 40 mmol/mol	HbA1c > 8.5, HbA1c > 69.40 mmol/mol	P value
NSGP values: HbA1c ≤ 7, 7 < HbA1c ≤ 8.5, HbA1c > 8.5, respectively; IFCC values in mmol/mol: HbA1c ≤ 53, 53 < HbA1c ≤ 69.40, HbA1c > 69.40, respectively. NSGP: National Glycohemoglobin Standardization Program; IFCC: The International Federation of Clinical Chemistry and Laboratory Medicine; WBC: white blood cells; NLR: neutrophils to lymphocytes ratio; CD64M0: CD64 antigen on monocytes on day 0; CD64M3: CD64 antigen on monocytes on day 3; CD64M7: CD64 antigen on monocytes on day 7; CD64O0: CD64 antigen on neutrophils on day 0; CD64O3: CD64 antigen on neutrophils on day 3; CD64O7: CD64 antigen on neutrophils on day7; HLA-DRM0: HLA-DR antigen on monocytes on day 0; HLA-DRM3: HLA-DR antigen on monocytes on day3; HLA-DRM7: HLA-DR antigen on monocytes on day 7; HLA-DRO0: HLA-DR antigen on neutrophils on day 0; HLA-DRO3: HLA-DR antigen on neutrophils on day 3; HLA-DRO7: HLA-DR antigen on neutrophils on day7; HLA-DR/CD64M0: HLA-DR/CD64 co-expression on monocytes on day 0; HLA-DR/CD64M3: HLA-DR/CD64 co-expression on monocytes on day 3; HLA-DR/CD64M7: HLA-DR/CD64 co-expression on monocytes on day 7; HLA-DR/CD64O0: HLA-DR/CD64 co-expression on neutrophils on day 0; HLA-DR/CD64O3: HLA-DR/CD64 co-expression on neutrophils on day3; HLA-DR/CD64O7: HLA-DR/CD64 co-expression on neutrophils on day 7; phagoM0: percentage of phagocytosis in monocytes on day 0; phagoM7: percentage of phagocytosis in monocytes on day 7; phagoO0: percentage of phagocytosis in neutrophils on day 0; phagoO7: percentage of phagocytosis in neutrophils on day 7. ^aP < 0.05 vs. grI. ^bP < 0.05 vs. grII.
Age	74 ± 9.13	74.32 ± 10	67.57 ± 16.12	0.463
WBC	14,702.86 ± 7,795.94	15,713.64 ± 6294.46	15,485 ± 6,223.94	0.983
NLR	12.16 ± 16.48	11.19 ± 9.51	7.89 ± 4.59	0.628
SAPS II score	31.79 ± 10.67	30.64 ± 8.98	31.21 ± 12.43	0.970
CRP	18.20 ± 13.50	16.99 ± 12.08	25.92 ± 11.67	0.130
HbA1c	6.42 ± 0.51	7.72 ± 0.38	11.25 ± 2.93	0.000
CD64M0	22.21 ± 11.88	18.38 ± 7.98	15.71 ± 6.98	0.270
CD64M3	12.98 ± 5.60	12.39 ± 4.85	12.20 ± 5.44	0.775
CD64M7	13.80 ± 6.16	13.62 ± 4.69	13.62 ± 5.49	0.860
CD64O0	14.02 ± 11.85	12.01 ± 6.85	7.59 ± 3.69^{a, b}	0.038
CD64O3	7.18 ± 3.50	7.96 ± 3.99	7.09 ± 3.84	0.810
CD64O7	11.53 ± 6.70	11.01 ± 5.02	8.52 ± 5.88	0.251
HLA-DRM0	5.89 ± 3.08	6.09 ± 2.59	4.34 ± 1.48	0.052
HLA-DRM3	4.56 ± 1.60	4.87 ± 1.77	3.85 ± 1.04	0.215
HLA-DRM7	6.80 ± 3.23	6.17 ± 1.88	6.16 ± 2.03	0.878
HLA-DRO0	4.93 ± 2.17	5.85 ± 3.48	4.43 ± 1.65	0.243
HLA-DRO3	3.45 ± 1.17	2.87 ± 0.71	2.80 ± 0.49	0.275
HLA-DRO7	6.15 ± 4.29	7.54 ± 2.84	6.82 ± 3.26	0.325
HLA-DR/CD64M0	5.67 ± 3.01	5.84 ± 2.52	4.13 ± 1.39^b	0.050
HLA-DR/CD64M3	4.40 ± 1.57	4.67 ± 1.69	3.66 ± 1.06	0.193
HLA-DR/CD64M7	6.52 ± 3.11	5.95 ± 1.80	6.22 ± 2.20	0.850
HLA-DR/CD64O0	3.61 ± 1.60	3.56 ± 2.36	2.93 ± 1.21	0.291
HLA-DR/CD64O3	2.46 ± 0.82	2.79 ± 1.85	2.16 ± 0.61	0.383
HLA-DR/CD64O7	3.91 ± 2.60	4.09 ± 1.63	4.00 ± 2.04	0.494
PhagoM0	73.97 ± 19.63	72.94 ± 15.89	69.48 ± 19.23	0.670
PhagoM7	74.57 ± 12.38	69.31 ± 15.90	65.55 ± 21.96	0.671
PhagoO0	88.72 ± 11.24	86.76 ± 12.78	88.65 ± 10.42	0.927
PhagoO7	92.55 ± 4.85	84.36 ± 12.73	83.75 ± 21.29	0.293

Table 3. Analysis of Characteristics in Septic Diabetic Patients With Excellent, Moderate and Inadequate Blood Glucose Control

Characteristics

HbA1c ≤ 7, HbA1c ≤ 53 mmol/mol

7 < HbA1c ≤ 8.5, 53 < HbA1c ≤ 69, 40 mmol/mol

HbA1c > 8.5, HbA1c > 69.40 mmol/mol

P value

NSGP values: HbA1c ≤ 7, 7 < HbA1c ≤ 8.5, HbA1c > 8.5, respectively; IFCC values in mmol/mol: HbA1c ≤ 53, 53 < HbA1c ≤ 69.40, HbA1c > 69.40, respectively. NSGP: National Glycohemoglobin Standardization Program; IFCC: The International Federation of Clinical Chemistry and Laboratory Medicine; WBC: white blood cells; NLR: neutrophils to lymphocytes ratio; CD64M0: CD64 antigen on monocytes on day 0; CD64M3: CD64 antigen on monocytes on day 3; CD64M7: CD64 antigen on monocytes on day 7; CD64O0: CD64 antigen on neutrophils on day 0; CD64O3: CD64 antigen on neutrophils on day 3; CD64O7: CD64 antigen on neutrophils on day7; HLA-DRM0: HLA-DR antigen on monocytes on day 0; HLA-DRM3: HLA-DR antigen on monocytes on day3; HLA-DRM7: HLA-DR antigen on monocytes on day 7; HLA-DRO0: HLA-DR antigen on neutrophils on day 0; HLA-DRO3: HLA-DR antigen on neutrophils on day 3; HLA-DRO7: HLA-DR antigen on neutrophils on day7; HLA-DR/CD64M0: HLA-DR/CD64 co-expression on monocytes on day 0; HLA-DR/CD64M3: HLA-DR/CD64 co-expression on monocytes on day 3; HLA-DR/CD64M7: HLA-DR/CD64 co-expression on monocytes on day 7; HLA-DR/CD64O0: HLA-DR/CD64 co-expression on neutrophils on day 0; HLA-DR/CD64O3: HLA-DR/CD64 co-expression on neutrophils on day3; HLA-DR/CD64O7: HLA-DR/CD64 co-expression on neutrophils on day 7; phagoM0: percentage of phagocytosis in monocytes on day 0; phagoM7: percentage of phagocytosis in monocytes on day 7; phagoO0: percentage of phagocytosis in neutrophils on day 0; phagoO7: percentage of phagocytosis in neutrophils on day 7. ^aP < 0.05 vs. grI. ^bP < 0.05 vs. grII.

Age

74 ± 9.13

74.32 ± 10

67.57 ± 16.12

0.463

WBC

14,702.86 ± 7,795.94

15,713.64 ± 6294.46

15,485 ± 6,223.94

0.983

NLR

12.16 ± 16.48

11.19 ± 9.51

7.89 ± 4.59

0.628

SAPS II score

31.79 ± 10.67

30.64 ± 8.98

31.21 ± 12.43

0.970

CRP

18.20 ± 13.50

16.99 ± 12.08

25.92 ± 11.67

0.130

HbA1c

6.42 ± 0.51

7.72 ± 0.38

11.25 ± 2.93

0.000

CD64M0

22.21 ± 11.88

18.38 ± 7.98

15.71 ± 6.98

0.270

CD64M3

12.98 ± 5.60

12.39 ± 4.85

12.20 ± 5.44

0.775

CD64M7

13.80 ± 6.16

13.62 ± 4.69

13.62 ± 5.49

0.860

CD64O0

14.02 ± 11.85

12.01 ± 6.85

7.59 ± 3.69^{a, b}

0.038

CD64O3

7.18 ± 3.50

7.96 ± 3.99

7.09 ± 3.84

0.810

CD64O7

11.53 ± 6.70

11.01 ± 5.02

8.52 ± 5.88

0.251

HLA-DRM0

5.89 ± 3.08

6.09 ± 2.59

4.34 ± 1.48

0.052

HLA-DRM3

4.56 ± 1.60

4.87 ± 1.77

3.85 ± 1.04

0.215

HLA-DRM7

6.80 ± 3.23

6.17 ± 1.88

6.16 ± 2.03

0.878

HLA-DRO0

4.93 ± 2.17

5.85 ± 3.48

4.43 ± 1.65

0.243

HLA-DRO3

3.45 ± 1.17

2.87 ± 0.71

2.80 ± 0.49

0.275

HLA-DRO7

6.15 ± 4.29

7.54 ± 2.84

6.82 ± 3.26

0.325

HLA-DR/CD64M0

5.67 ± 3.01

5.84 ± 2.52

4.13 ± 1.39^b

0.050

HLA-DR/CD64M3

4.40 ± 1.57

4.67 ± 1.69

3.66 ± 1.06

0.193

HLA-DR/CD64M7

6.52 ± 3.11

5.95 ± 1.80

6.22 ± 2.20

0.850

HLA-DR/CD64O0

3.61 ± 1.60

3.56 ± 2.36

2.93 ± 1.21

0.291

HLA-DR/CD64O3

2.46 ± 0.82

2.79 ± 1.85

2.16 ± 0.61

0.383

HLA-DR/CD64O7

3.91 ± 2.60

4.09 ± 1.63

4.00 ± 2.04

0.494

PhagoM0

73.97 ± 19.63

72.94 ± 15.89

69.48 ± 19.23

0.670

PhagoM7

74.57 ± 12.38

69.31 ± 15.90

65.55 ± 21.96

0.671

PhagoO0

88.72 ± 11.24

86.76 ± 12.78

88.65 ± 10.42

0.927

PhagoO7

92.55 ± 4.85

84.36 ± 12.73

83.75 ± 21.29

0.293

**Table 4.** Analysis of Characteristics Between Septic Patients With Diabetes Mellitus and Diabetic Patients Without Sepsis
Characteristics	Septic patients with diabetes	Diabetic patients	P value
WBC: white blood cells; NLR: neutrophils to lymphocytes ratio; CD64MO: CD64 antigen on monocytes on day 0; CD64M3: CD64 antigen on monocytes on day 3; CD64M7: CD64 antigen on monocytes on day 7; CD64O0: CD64 antigen on neutrophils on day 0; CD64O3: CD64 antigen on neutrophils on day3; CD64O7: CD64 antigen on neutrophils on day7; HLA-DRM0: HLA-DR antigen on monocytes on day 0; HLA-DRM3: HLA-DR antigen on monocytes on day 3; HLA-DRM7: HLADR antigen on monocytes on day7; HLA-DRO0: HLA-DR antigen on neutrophils on day 0; HLA-DRO3: HLA-DR antigen on neutrophils on day 3; HLA-DRO7: HLA-DR antigen on neutrophils on day 7; HLA-DR/CD64M0: HLA-DR/CD64 co-expression on monocytes on day 0; HLA-DR/CD64M3: HLA-DR/CD64 co-expression on monocytes on day 3; HLA-DR/CD64M7: HLA-DR/CD64: co-expression on monocytes on day 7; HLADR/CD64O0: HLA-DR/CD64 co-expression on neutrophils on day 0; HLA-DR/CD64O3: HLA-DR/CD64 co-expression on neutrophils on day 3; HLA-DR/CD64O7: HLA-DR/CD64 co-expression on neutrophils on day 7; phagoM0: percentage of phagocytosis in monocytes on day 0; phagoM7: percentage of phagocytosis in monocytes on day 7; phagoO0: percentage of phagocytosis in neutrophils on day 0; phagoO7: percentage of phagocytosis in neutrophils on day 7.
Age	72.43 ± 11.87	57.88 ± 15.64	0.000
WBC	15,084.76 ± 6,837.066	7,491.54 ± 2,326.56	0.093
NLR	10.42 ± 10.85	2.53 ± 1.30
SAPS II score	31.06 ± 10.20	9.72 ± 5.40
CRP	19.38 ± 12.65
HBA1c	8.34 ± 2.46	7.75 ± 1.98	0.093
CD64M0	18.57 ± 9.11	10.48 ± 2.82	0.000
CD64M3	12.53 ± 5.08
CD64M7	13.67 ± 5.21
CD64O0	11.22 ± 8.16	8.37 ± 2.53	0.083
CD64O3	7.51 ± 3.73
CD64O7	10.40 ± 5.75
HLA-DRM0	5.48 ± 2.57	6.86 ± 1.66	0.000
HLA-DRM3	4.46 ± 1.57
HLA-DRM7	6.33 ± 2.29
HLA-DRO0	5.14 ± 2.74	6.73 ± 8.24	0.666
HLA-DRO3	2.99 ± 0.84
HLA-DRO7	6.97 ± 3.35
HLA-DR/CD64M0	5.25 ± 2.51	6.61 ± 1.61	0.000
HLA-DR/CD64M3	4.28 ± 1.52
HLA-DR/CD64M7	6.18 ± 2.27
HLA-DR/CD64O0	3.36 ± 1.88	3.50 ± 4.81	0.000
HLA-DR/CD64O3	2.50 ± 1.34
HLA-DR/CD64O7	4.02 ± 1.98
PhagoM0	72.52 ± 17.58	46.81 ± 13.14	0.000
PhagoM7	69.53 ± 17.15
PhagoO0	87.96 ± 11.46	74.94 ± 11.67	0.000
PhagoO7	86.27 ± 14.77

Table 4. Analysis of Characteristics Between Septic Patients With Diabetes Mellitus and Diabetic Patients Without Sepsis

Characteristics

Septic patients with diabetes

Diabetic patients

P value

WBC: white blood cells; NLR: neutrophils to lymphocytes ratio; CD64MO: CD64 antigen on monocytes on day 0; CD64M3: CD64 antigen on monocytes on day 3; CD64M7: CD64 antigen on monocytes on day 7; CD64O0: CD64 antigen on neutrophils on day 0; CD64O3: CD64 antigen on neutrophils on day3; CD64O7: CD64 antigen on neutrophils on day7; HLA-DRM0: HLA-DR antigen on monocytes on day 0; HLA-DRM3: HLA-DR antigen on monocytes on day 3; HLA-DRM7: HLADR antigen on monocytes on day7; HLA-DRO0: HLA-DR antigen on neutrophils on day 0; HLA-DRO3: HLA-DR antigen on neutrophils on day 3; HLA-DRO7: HLA-DR antigen on neutrophils on day 7; HLA-DR/CD64M0: HLA-DR/CD64 co-expression on monocytes on day 0; HLA-DR/CD64M3: HLA-DR/CD64 co-expression on monocytes on day 3; HLA-DR/CD64M7: HLA-DR/CD64: co-expression on monocytes on day 7; HLADR/CD64O0: HLA-DR/CD64 co-expression on neutrophils on day 0; HLA-DR/CD64O3: HLA-DR/CD64 co-expression on neutrophils on day 3; HLA-DR/CD64O7: HLA-DR/CD64 co-expression on neutrophils on day 7; phagoM0: percentage of phagocytosis in monocytes on day 0; phagoM7: percentage of phagocytosis in monocytes on day 7; phagoO0: percentage of phagocytosis in neutrophils on day 0; phagoO7: percentage of phagocytosis in neutrophils on day 7.

Age

72.43 ± 11.87

57.88 ± 15.64

0.000

WBC

15,084.76 ± 6,837.066

7,491.54 ± 2,326.56

0.093

NLR

10.42 ± 10.85

2.53 ± 1.30

SAPS II score

31.06 ± 10.20

9.72 ± 5.40

CRP

19.38 ± 12.65

HBA1c

8.34 ± 2.46

7.75 ± 1.98

0.093

CD64M0

18.57 ± 9.11

10.48 ± 2.82

0.000

CD64M3

12.53 ± 5.08

CD64M7

13.67 ± 5.21

CD64O0

11.22 ± 8.16

8.37 ± 2.53

0.083

CD64O3

7.51 ± 3.73

CD64O7

10.40 ± 5.75

HLA-DRM0

5.48 ± 2.57

6.86 ± 1.66

0.000

HLA-DRM3

4.46 ± 1.57

HLA-DRM7

6.33 ± 2.29

HLA-DRO0

5.14 ± 2.74

6.73 ± 8.24

0.666

HLA-DRO3

2.99 ± 0.84

HLA-DRO7

6.97 ± 3.35

HLA-DR/CD64M0

5.25 ± 2.51

6.61 ± 1.61

0.000

HLA-DR/CD64M3

4.28 ± 1.52

HLA-DR/CD64M7

6.18 ± 2.27

HLA-DR/CD64O0

3.36 ± 1.88

3.50 ± 4.81

0.000

HLA-DR/CD64O3

2.50 ± 1.34

HLA-DR/CD64O7

4.02 ± 1.98

PhagoM0

72.52 ± 17.58

46.81 ± 13.14

0.000

PhagoM7

69.53 ± 17.15

PhagoO0

87.96 ± 11.46

74.94 ± 11.67

0.000

PhagoO7

86.27 ± 14.77