Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
Journal website http://www.jocmr.org

Original Article

Volume 12, Number 2, February 2020, pages 90-99


Independent External Validation of a Score Predicting Survival After Radiotherapy for Bone Metastases and Expansion to Patients Treated With Single Fraction Radiotherapy

Figures

Figure 1.
Figure 1. Actuarial Kaplan-Meier survival curves for 270 patients with bone metastases stratified by radiotherapy fractionation (P = 0.0001).
Figure 2.
Figure 2. Actuarial Kaplan-Meier survival curves for 270 patients with bone metastases stratified by Rades et al score (P = 0.0001).
Figure 3.
Figure 3. Actuarial Kaplan-Meier survival curves for 64 patients with bone metastases who received 8 Gy single fraction radiotherapy stratified by Rades et al score (P = 0.0001).
Figure 4.
Figure 4. Actuarial Kaplan-Meier survival curves for 71 patients with bone metastases who received short course radiotherapy stratified by Rades et al score (P = 0.0001).
Figure 5.
Figure 5. Actuarial Kaplan-Meier survival curves for 135 patients with bone metastases who received long course radiotherapy stratified by Rades et al score (P = 0.0001).

Tables

Table 1. Distribution of Score Parameters
 
ParametersFavorable scoreIntermediate scoreUnfavorable score
Median age, years676569
Age ≤ 60 years, %222610
Karnofsky performance status 80 - 100, %100490
Breast cancer, %26100
Renal cell cancer, %1480
Prostate cancer, %60290
Lung cancer, %02247
Colorectal cancer, %057
Other cancer, %02646
Median point sum15129

 

Table 2. Results Overview
 
Group12-month survivalMedian survival
Rades et al favorable72%24 months
Rades et al intermediate38%8 months
Rades et al unfavorable9%3 months
Present study favorable71%31.8 months
Present study intermediate30%4.4 months
Present study unfavorable7%1.4 months
Present study 8 Gy favorable43%10.0 months
Present study 8 Gy intermediate13%3.0 months
Present study 8 Gy unfavorable0%1.0 month
Present study short course favorable72%31.8 months
Present study short course intermediate21%3.2 months
Present study short course unfavorable8%1.5 months
Present study long course favorable81%54.8 months
Present study long course intermediate45%9.7 months
Present study long course unfavorable10%1.4 months