J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 12, Number 3, March 2020, pages 142-149

MAC Attack: Clinical Correlates of Mycobacterium avium Complex Infection Among Patients With and Without Cancer

**Table 1.** Patient Characteristics Stratified by Any Cancer
	Any cancer	P value
Patients number	550 (100)	106 (19.3)	444 (80.7)
Age at diagnosis (years), median (range)	68.4 (17.2 - 93.4)	71.8 (26.9 - 89.3)	67.6 (17.2 - 93.4)	0.028
Gender
Male	243 (44.2)	28 (26.4)	215 (48.4)	< 0.001
Female	307 (55.8)	78 (73.6)	229 (51.6)
Race
White	455 (82.7)	91 (85.8)	364 (82)	0.70
Black	19 (3.5)	2 (1.9)	17 (3.8)
Asian	56 (10.2)	11 (10.4)	45 (10.1)
Other	5 (0.9)	0 (0)	5 (1.1)
Unknown	15 (2.7)	2 (1.9)	13 (2.9)
Smoking status
None	239 (43.5)	47 (44.3)	192 (43.2)	0.73
Former	280 (50.9)	55 (51.9)	225 (50.7)
Current	31 (5.6)	4 (3.8)	27 (6.1)
BMI, median (range)	24.2 (12.3 - 57.0)	24.2 (13.7 - 49.4)	24.3 (12.3 - 57.0)	0.79
Pre-existing lung disease
Yes	283 (51.5)	66 (62.3)	217 (48.9)	0.017
No	267 (48.5)	40 (37.7)	227 (51.1)
MAC pulmonary infection
Yes	196 (35.6)	65 (61.3)	131 (29.5)	< 0.001
No	354 (64.4)	41 (38.7)	313 (70.5)

Table 1. Patient Characteristics Stratified by Any Cancer

Any cancer

P value

Total

Yes

Patients number

550 (100)

106 (19.3)

444 (80.7)

Age at diagnosis (years), median (range)

68.4 (17.2 - 93.4)

71.8 (26.9 - 89.3)

67.6 (17.2 - 93.4)

0.028

Gender

Male

243 (44.2)

28 (26.4)

215 (48.4)

< 0.001

Female

307 (55.8)

78 (73.6)

229 (51.6)

Race

White

455 (82.7)

91 (85.8)

364 (82)

0.70

Black

19 (3.5)

2 (1.9)

17 (3.8)

Asian

56 (10.2)

11 (10.4)

45 (10.1)

Other

5 (0.9)

0 (0)

5 (1.1)

Unknown

15 (2.7)

2 (1.9)

13 (2.9)

Smoking status

None

239 (43.5)

47 (44.3)

192 (43.2)

0.73

Former

280 (50.9)

55 (51.9)

225 (50.7)

Current

31 (5.6)

4 (3.8)

27 (6.1)

BMI, median (range)

24.2 (12.3 - 57.0)

24.2 (13.7 - 49.4)

24.3 (12.3 - 57.0)

0.79

Pre-existing lung disease

Yes

283 (51.5)

66 (62.3)

217 (48.9)

0.017

267 (48.5)

40 (37.7)

227 (51.1)

MAC pulmonary infection

Yes

196 (35.6)

65 (61.3)

131 (29.5)

< 0.001

354 (64.4)

41 (38.7)

313 (70.5)

**Table 2.** Overall Radiologic Findings
Diffuse parenchymal: ground glass opacities, airspace opacities, alveolar infiltrates, interstitial infiltrates, tree and bud infiltrates, mosaic pattern, mucus plugging, pulmonary edema, consolidation, emphysema, fibrosis, septal thickening. Focal parenchymal: nodule, mass, spiculated mass, granuloma, lung abscess. Pleural disease: pleural effusion, pleural thickening, hydropneumothorax, pneumothorax. Airway disease: atelectasis, bronchiectasis, endobronchial lesion, tracheomalacia, tracheobronchomalacia. Lymphadenopathy: mediastinal and hilar adenopathy.
Any radiology finding	548 (99.6)
Diffuse parenchymal	282 (51.3)
Focal parenchymal	409 (74.4)
Cavitary	32 (5.8)
Pleural disease	49 (8.9)
Airway disease	147 (26.7)
Lymphadenopathy	85 (15.5)

Table 2. Overall Radiologic Findings

Diffuse parenchymal: ground glass opacities, airspace opacities, alveolar infiltrates, interstitial infiltrates, tree and bud infiltrates, mosaic pattern, mucus plugging, pulmonary edema, consolidation, emphysema, fibrosis, septal thickening. Focal parenchymal: nodule, mass, spiculated mass, granuloma, lung abscess. Pleural disease: pleural effusion, pleural thickening, hydropneumothorax, pneumothorax. Airway disease: atelectasis, bronchiectasis, endobronchial lesion, tracheomalacia, tracheobronchomalacia. Lymphadenopathy: mediastinal and hilar adenopathy.

Any radiology finding

548 (99.6)

Diffuse parenchymal

282 (51.3)

Focal parenchymal

409 (74.4)

Cavitary

32 (5.8)

Pleural disease

49 (8.9)

Airway disease

147 (26.7)

Lymphadenopathy

85 (15.5)

**Table 3.** Association Between Patient Characteristics and Antibiotics Treatment
	Antibiotics	P value
Age at diagnosis (years), median (range)	68.8 (17.2 - 93.4)	66.8 (22.3 - 88.7)	0.47
Gender
Male	226 (45.1)	17 (34.7)	0.18
Female	275 (54.9)	32 (65.3)
Race
White	408 (84)	47 (95.9)	0.20
Black	19 (3.9)	0 (0)
Asian	54 (11.1)	2 (4.1)
Other	5 (1)	0 (0)
Smoking status
None	222 (44.3)	17 (34.7)	0.36
Former	250 (49.9)	30 (61.2)
Current	29 (5.8)	2 (4.1)
BMI, median (range)	24.7 (12.3 - 57.0)	21.5 (13.7 - 41.1)	< 0.001
Pre-existing lung disease
Yes	248 (49.5)	35 (71.4)	0.004
No	253 (50.5)	14 (28.6)
Any cancer
Yes	411 (82)	33 (67.3)	0.021
No	90 (18)	16 (32.7)
MAC pulmonary infection
Yes	147 (29.3)	49 (100)	< 0.001
No	354 (70.7)	0 (0)

Table 3. Association Between Patient Characteristics and Antibiotics Treatment

Antibiotics

P value

Yes

Age at diagnosis (years), median (range)

68.8 (17.2 - 93.4)

66.8 (22.3 - 88.7)

0.47

Gender

Male

226 (45.1)

17 (34.7)

0.18

Female

275 (54.9)

32 (65.3)

Race

White

408 (84)

47 (95.9)

0.20

Black

19 (3.9)

0 (0)

Asian

54 (11.1)

2 (4.1)

Other

5 (1)

0 (0)

Smoking status

None

222 (44.3)

17 (34.7)

0.36

Former

250 (49.9)

30 (61.2)

Current

29 (5.8)

2 (4.1)

BMI, median (range)

24.7 (12.3 - 57.0)

21.5 (13.7 - 41.1)

< 0.001

Pre-existing lung disease

Yes

248 (49.5)

35 (71.4)

0.004

253 (50.5)

14 (28.6)

Any cancer

Yes

411 (82)

33 (67.3)

0.021

90 (18)

16 (32.7)

MAC pulmonary infection

Yes

147 (29.3)

49 (100)

< 0.001

354 (70.7)

0 (0)