Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
Journal website http://www.jocmr.org

Short Communication

Volume 11, Number 10, October 2019, pages 720-724

Acute Kidney Injury-Associated Systemic Inflammation Is Aggravated in Insulin-Dependent Diabetes Mellitus

Figures

Figure 1.
Figure 1. Methodical approach in the current study. Insulin-dependent diabetes mellitus was induced in male C57/Bl6N mice by IP injection of streptozotocin for 5 consecutive days. Blood glucose testing was performed at day 7 after the first injection. Six weeks later, animals underwent bilateral renal ischemia (ischemia reperfusion injury), followed by systemic administration of native or preconditioned syngeneic murine PACs. Cytokine analysis was performed 2 days (48 h) later. IP: introperitoneally; PAC: proangiogenic cell.
Figure 2.
Figure 2. Serum cytokine levels at 48 h after ischemia-reperfusion injury in non-diabetic and diabetic mice. IRI: ischemia reperfusion injury; STZ: streptozotocine; PAC: proangiogenic cell. The symbols indicate significant differences (P < 0.05) in comparison to certain groups: * as compared to “Control”; ° as compared to “IRI”; + as compared to “IRI STZ PACs” in I and K and to “IRI STZ” in L and to “IRI” in R; # as compared to “IRI STZ PACs” in A and to “IRI” in B, E, L, and M (all data as mean ± SEM).