J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 11, Number 1, January 2019, pages 35-41

Residual Effect of Sodium Glucose Cotransporter 2 Inhibitor, Tofogliflozin, on Body Weight After Washout in Japanese Men With Type 2 Diabetes

Figure 5. Proposed chart for changes in body weight and potential body composition after treatment and after washout of tofogliflozin. The mechanism by which body weight reductions caused by tofogliflozin may be due to several factors as well as fat reductions at 8 weeks, but those may be due most likely to fat reductions alone after a subsequent 8 weeks of washout (16 week) of this agent.

**Table 1.** Patient Background
Data are presented as mean ± SEM.
Number of subjects	10
Age (years)	60.9 ± 2.8
HbA1c (%)	6.8 ± 0.2
Body weight (kg)	75.4 ± 4.1
BMI (kg/m²)	26.7 ± 1.1
Waist circumference (cm)	91.7 ± 3.0
Fasting blood glucose (mg/dL)	140.8 ± 16.2
Estimated GFR (mL/min/1.73 m²)	77.3 ± 4.3
Systolic blood pressure (mm Hg)	139.9 ± 4.5
Diastolic blood pressure (mm Hg)	83.4 ± 1.9
Presence/absence of antihypertensive agent	5/5
Presence/absence of use of hyperlipemia treatment agent	5/5
Presence/absence of use of hyperuricemia treatment agent	1/9

Table 1. Patient Background

Data are presented as mean ± SEM.

Number of subjects

Age (years)

60.9 ± 2.8

HbA1c (%)

6.8 ± 0.2

Body weight (kg)

75.4 ± 4.1

BMI (kg/m²)

26.7 ± 1.1

Waist circumference (cm)

91.7 ± 3.0

Fasting blood glucose (mg/dL)

140.8 ± 16.2

Estimated GFR (mL/min/1.73 m²)

77.3 ± 4.3

Systolic blood pressure (mm Hg)

139.9 ± 4.5

Diastolic blood pressure (mm Hg)

83.4 ± 1.9

Presence/absence of antihypertensive agent

5/5

Presence/absence of use of hyperlipemia treatment agent

5/5

Presence/absence of use of hyperuricemia treatment agent

1/9

**Table 2.** Changes in Each Parameter Versus Baseline
	Baseline	After treatment	After washout
Data are expressed as mean ± SEM or median (1st, 3rd quartile). P < 0.05, P < 0.01, **P < 0.001 (versus baseline) with paired t-test or Wilcoxon’s signed-rank tests. ^#Urine was collected during 120 min after loading test meal and volume and glucose content were measured [1].
HbA1c (%)	6.8 ± 0.2	6.5 ± 0.2	-0.3*	6.9 ± 0.3	0.05
Fasting blood glucose (mg/dL)	140.8 ± 16.2	111.8 ± 7.9	-29.0	124.5 ± 8.8	-16.3
Body weight (kg)	75.4 ± 4.1	73.0 ± 4.2	-2.4***	74.0 ± 4.7	-1.4
Waist circumference (cm)	91.7 ± 3.0	89.3 ± 3.0	-2.4**	90.3 ± 3.8	-1.4
HMW adiponectin (µg/mL)	1.98 (1.35, 3.30)	2.54 (1.56, 4.08)	0.475***	2.66 (1.27, 4.25)	0.205
Uric acid (mg/dL)	5.38 ± 0.4	4.61 ± 0.4	-0.77***	5.25 ± 0.5	-0.13
Ht (%)	43.92 ± 1.1	46.84 ± 0.83	2.92***	45.39 ± 1.0	1.47***
RBC (/µL)	480.4 ± 13.8	510.3 ± 10.28	29.9***	492.2 ± 11.3	11.8*
^#Urine glucose AUC120 min (g)	3.8 ± 2.5	24.7 ± 4.8	20.9**	1.7 ± 1	-2.1
^#Urine volume AUC120 min (mL)	224.7 ± 50.2	400.4 ± 73.4	175.7	275.1 ± 98.1	50.4

Table 2. Changes in Each Parameter Versus Baseline

Baseline

After treatment

After washout

0 week

8 weeks

Changes from baseline

16 weeks

Changes from baseline

Data are expressed as mean ± SEM or median (1st, 3rd quartile). *P < 0.05, **P < 0.01, ***P < 0.001 (versus baseline) with paired t-test or Wilcoxon’s signed-rank tests. ^#Urine was collected during 120 min after loading test meal and volume and glucose content were measured [1].

HbA1c (%)

6.8 ± 0.2

6.5 ± 0.2

-0.3*

6.9 ± 0.3

0.05

Fasting blood glucose (mg/dL)

140.8 ± 16.2

111.8 ± 7.9

-29.0

124.5 ± 8.8

-16.3

Body weight (kg)

75.4 ± 4.1

73.0 ± 4.2

-2.4***

74.0 ± 4.7

-1.4

Waist circumference (cm)

91.7 ± 3.0

89.3 ± 3.0

-2.4**

90.3 ± 3.8

-1.4

HMW adiponectin (µg/mL)

1.98 (1.35, 3.30)

2.54 (1.56, 4.08)

0.475***

2.66 (1.27, 4.25)

0.205

Uric acid (mg/dL)

5.38 ± 0.4

4.61 ± 0.4

-0.77***

5.25 ± 0.5

-0.13

Ht (%)

43.92 ± 1.1

46.84 ± 0.83

2.92***

45.39 ± 1.0

1.47***

RBC (/µL)

480.4 ± 13.8

510.3 ± 10.28

29.9***

492.2 ± 11.3

11.8*

^#Urine glucose AUC120 min (g)

3.8 ± 2.5

24.7 ± 4.8

20.9**

1.7 ± 1

-2.1

^#Urine volume AUC120 min (mL)

224.7 ± 50.2

400.4 ± 73.4

175.7

275.1 ± 98.1

50.4