Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access |

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc |

Journal website http://www.jocmr.org |

Original Article

Volume 10, Number 11, November 2018, pages 815-821

**The Effect of p53 Status on Radio-Sensitivity of Quiescent Tumor Cell Population Irradiated With γ-Rays at Various Dose Rates**

Figures

Tables

Total tumor cells | Quiescent cells | |
---|---|---|

^{a}Mean ± standard error (n = 6). | ||

SAS/neo | ||

Plating efficiency (%) | 45.5 ± 8.9^{a} | |

Micronucleus frequency | 0.038 ± 0.006 | 0.056 ± 0.007 |

SAS/mp53 | ||

Plating efficiency (%) | 23.5 ± 4.1 | |

Micronucleus frequency | 0.072 ± 0.008 | 0.111 ± 0.010 |

HDR | MDR | LDR | |
---|---|---|---|

9h later | |||

^{a}The ratio of the dose of radiation necessary to obtain each end-point with a delayed assay or reduced dose-rate irradiation to that needed to obtain each end-point with an assay immediately after high dose-rate irradiation. ^{b}Mean ± standard error (n = 6). | |||

Surviving fraction = 0.2 | |||

SAS/neo | 1.5 ± 0.15^{b} | 1.6 ± 0.15 | 2.1 ± 0.2 |

SAS/mp53 | 1.1 ± 0.1 | 1.2 ± 0.1 | 1.3 ± 0.1 |

Net micronucleus frequency = 0.1 | |||

Total tumor cells | |||

SAS/neo | 1.4 ± 0.1 | 1.45 ± 0.1 | 1.8 ± 0.15 |

SAS/mp53 | 1.05 ± 0.1 | 1.1 ± 0.1 | 1.15 ± 0.1 |

Quiescent cells | |||

SAS/neo | 1.55 ± 0.15 | 1.65 ± 0.15 | 1.85 ± 0.2 |

SAS/mp53 | 1.05 ± 0.1 | 1.1 ± 0.1 | 1.2 ± 0.1 |

HDR | HDR | MDR | LDR |
---|---|---|---|

Right after | 9 h later | ||

^{a}The ratio of the physical radiation dose of external beams necessary to obtain each end-point in SAS/mp53 tumor cells to that needed to obtain each end-point in SAS/neo tumor cells. ^{b}Mean ± standard error (n = 6). | |||

Surviving fraction = 0.2 | |||

1.4 ± 0.1^{b} | 1.05 ± 0.1 | 1.05 ± 0.1 | 1.0 ± 0.1 |

HDR | HDR | MDR | LDR |
---|---|---|---|

Right after | 9 h later | ||

^{a}The ratio of the dose of radiation necessary to obtain each end-point in the quiescent cell population to that needed to obtain each end-point in the total tumor cell population. ^{b}Mean ± standard error (n = 6). | |||

SAS/neo | |||

2.2 ± 0.2^{b} | 2.2 ± 0.2 | 2.4 ± 0.25 | 2.45 ± 0.25 |

SAS/mp53 | |||

1.85 ± 0.2 | 1.9 ± 0.2 | 1.9 ± 0.2 | 1.95 ± 0.2 |