Figure 1. Correlations between weight changes and hazard ratios in eight clinical studies. Data plotted with diamonds were obtained from the relevant literature. Data on the body weight changes in the EMPA-REG OUTCOME study were obtained from the figure in the supplementary data and estimated as being a mean of -2 kg. From left to right: SUSTAIN-6, semaglutide 1 mg; SUSTAIN-6, semaglutide 0.5 mg [7]; LEADER [6]; EMPA-REG OUTCOME [4]; CANVAS [5]; EXCEL [9]; ELIXA [8]; SAVOR-TIMI53 [1] and EXAMINE [2]. The TECOS study [3] was excluded, as there were no data on the body weight changes.