J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 10, Number 8, August 2018, pages 641-647

Efficacy and Patient Satisfaction of Dipeptidyl Peptidase-4 Inhibitor After Switching From Once-Daily DPP-4 Inhibitor to Once-Weekly Regimen

**Table 1.** The Checklist for Life-Style Assessment
Please tell us about your current eating habits and exercise habits.
The sum of the points represented the lifestyle assessment score.
1. Do you skip your ordinary meal (for example, skip breakfast, etc.)?
Never: (1 point)
Sometimes or often: (0 points)
2. Do you eat your dinner later than 9 PM?
Never: (1 point)
Sometimes or often: (0 points)
3. Are you taking care of the amount and content of your meal (for example, cutting down sugar, salt or oil, etc.)?
Often: (2 points)
Sometimes: (1 point)
Never: (0 points)
4. Do you have a snack between meals?
Never: (1 point)
Sometimes or often: (0 points)
5. Do you eat out in the evening?
Never: (1 point)
Sometimes or often: (0 points)
6. Do you drink alcohol?
Never: (1 point)
Sometimes or often: (0 points)
7. How often do you exercise a week?
Every day: (2 points)
1 to 6 days: (1 point)
Never: (0 points)
8. How long do you exercise a day?
More than 1 hour: (2 points)
Within 1 hour: (1 point)
Never: (0 points ) (who answered ‘never’ in question 7)

Table 1. The Checklist for Life-Style Assessment

Please tell us about your current eating habits and exercise habits.

The sum of the points represented the lifestyle assessment score.

1. Do you skip your ordinary meal (for example, skip breakfast, etc.)?

Never: (1 point)

Sometimes or often: (0 points)

2. Do you eat your dinner later than 9 PM?

Never: (1 point)

Sometimes or often: (0 points)

3. Are you taking care of the amount and content of your meal (for example, cutting down sugar, salt or oil, etc.)?

Often: (2 points)

Sometimes: (1 point)

Never: (0 points)

4. Do you have a snack between meals?

Never: (1 point)

Sometimes or often: (0 points)

5. Do you eat out in the evening?

Never: (1 point)

Sometimes or often: (0 points)

6. Do you drink alcohol?

Never: (1 point)

Sometimes or often: (0 points)

7. How often do you exercise a week?

Every day: (2 points)

1 to 6 days: (1 point)

Never: (0 points)

8. How long do you exercise a day?

More than 1 hour: (2 points)

Within 1 hour: (1 point)

Never: (0 points ) (who answered ‘never’ in question 7)

**Table 2.** Patient Characteristics
Factors	Mean ± SD (range)
Data are presented as mean ± SD. AER: albumin excretion rate; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; eGFR: estimated glomerular filtration rate. The insulin preparation counted it for one kind in all.
Number of patients (n)	153
Age (years old)	63.9 ± 10.3 (28 - 87)
Sex (male/female)	94:59
Duration of diabetes (years)	14.9 ± 7.7 (1 - 43)
BMI (kg/m²)	25.5 ± 4.2 (16.1 - 39.7)
Body weight (kg)	65.2 ± 9.5 (49.2 - 84.3)
HbA1c (%)	7.41 ± 0.75 (5.7 - 9.6)
SBP (mm Hg)	122.1 ± 11.3 (94 - 143)
DBP (mm Hg)	72.5 ± 7.8 (59 - 88)
eGFR (mL/min/1.73 m²)	70.23 ± 22.9 (40.9 - 121.2)
Number of drugs (n)	5.1 ± 2.2 (1 - 12)
U-AER (mg/gCr)	94.4 ± 187.9 (2.3 - 873.2)

Table 2. Patient Characteristics

Factors

Mean ± SD (range)

Data are presented as mean ± SD. AER: albumin excretion rate; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; eGFR: estimated glomerular filtration rate. The insulin preparation counted it for one kind in all.

Number of patients (n)

153

Age (years old)

63.9 ± 10.3 (28 - 87)

Sex (male/female)

94:59

Duration of diabetes (years)

14.9 ± 7.7 (1 - 43)

BMI (kg/m²)

25.5 ± 4.2 (16.1 - 39.7)

Body weight (kg)

65.2 ± 9.5 (49.2 - 84.3)

HbA1c (%)

7.41 ± 0.75 (5.7 - 9.6)

SBP (mm Hg)

122.1 ± 11.3 (94 - 143)

DBP (mm Hg)

72.5 ± 7.8 (59 - 88)

eGFR (mL/min/1.73 m²)

70.23 ± 22.9 (40.9 - 121.2)

Number of drugs (n)

5.1 ± 2.2 (1 - 12)

U-AER (mg/gCr)

94.4 ± 187.9 (2.3 - 873.2)

**Table 3.** Changes in Clinical Parameters After Switching From Sitagliptin to Omarigliptin
	Baseline	8 weeks	P value
Data are presented as mean ± SD. BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; NS: not significant by Student’s paired t-test.
BMI (kg/m²)	25.5 ± 4.2	25.3 ± 3.6	NS
Body weight (kg)	65.2 ± 9.5	65.7 ± 9.6	NS
HbA1c (%)	7.41 ± 0.75	7.36 ± 0.79	NS
SBP (mm Hg)	122.1 ± 11.3	127.6 ± 11.9	NS
DBP (mm Hg)	72.5 ± 7.8	75.5 ± 9.7	NS

Table 3. Changes in Clinical Parameters After Switching From Sitagliptin to Omarigliptin

Baseline

8 weeks

P value

Data are presented as mean ± SD. BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; NS: not significant by Student’s paired t-test.

BMI (kg/m²)

25.5 ± 4.2

25.3 ± 3.6

Body weight (kg)

65.2 ± 9.5

65.7 ± 9.6

HbA1c (%)

7.41 ± 0.75

7.36 ± 0.79

SBP (mm Hg)

122.1 ± 11.3

127.6 ± 11.9

DBP (mm Hg)

72.5 ± 7.8

75.5 ± 9.7

**Table 4.** Comparison of Clinical Parameters Between Patients With Increased and With Decreased Satisfaction Based on Q1 Questions
	Satisfied (+) N = 46	Satisfied (-) N = 24	P value
Data are presented as mean ± SD. BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; NS: not significant by Student’s paired t-test.
Sex (male/female)	27:19	14:10
Age (years old)	63.6 ± 12.8	63.4 ± 9.9	NS
Duration of diabetes (year)	15.8 ± 7.9	14.0 ± 7.7	NS
eGFR	82.94 ± 24.8	77.25 ± 15.9	NS
U-AER	73.5 ± 167.6	42.0 ± 65.7	NS
BMI (kg/m²), 0 weeks	25.7 ± 4.3	24.9 ± 4.0	NS
BMI (kg/m²), 8 weeks	25.9 ± 4.3	24.6 ± 4.2	NS
Body weight (kg), 0 weeks	68.8 ± 13.0	66.4 ± 12.7	NS
Body weight (kg), 8 weeks	68.8 ± 13.0	66.2 ± 13.0	NS
SBP (mm Hg), 0 weeks	121.3 ± 12.5	124.9 ± 12.0	NS
SBP (mm Hg), 8 weeks	122.5 ± 15.1	126.2 ± 12.7	NS
DBP (mm Hg), 0 weeks	72.1 ± 12.2	74.4 ± 10.6	NS
DBP (mm Hg), 8 weeks	72.1 ± 11.1	74.9 ± 13.1	NS
HbA1 (%), 0 weeks	7.57 ± 0.77	7.32 ± 0.54	NS
HbA1c (%), 8 weeks	7.41 ± 0.73	7.47 ± 0.67	NS
ΔHbA1c	-0.154 ± 0.32	0.146 ± 0.49	<0.01
Number of drugs	5.3 ± 2.0	6.0 ± 2.9	NS

Table 4. Comparison of Clinical Parameters Between Patients With Increased and With Decreased Satisfaction Based on Q1 Questions

Satisfied (+) N = 46

Satisfied (-) N = 24

P value

Data are presented as mean ± SD. BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; NS: not significant by Student’s paired t-test.

Sex (male/female)

27:19

14:10

Age (years old)

63.6 ± 12.8

63.4 ± 9.9

Duration of diabetes (year)

15.8 ± 7.9

14.0 ± 7.7

eGFR

82.94 ± 24.8

77.25 ± 15.9

U-AER

73.5 ± 167.6

42.0 ± 65.7

BMI (kg/m²), 0 weeks

25.7 ± 4.3

24.9 ± 4.0

BMI (kg/m²), 8 weeks

25.9 ± 4.3

24.6 ± 4.2

Body weight (kg), 0 weeks

68.8 ± 13.0

66.4 ± 12.7

Body weight (kg), 8 weeks

68.8 ± 13.0

66.2 ± 13.0

SBP (mm Hg), 0 weeks

121.3 ± 12.5

124.9 ± 12.0

SBP (mm Hg), 8 weeks

122.5 ± 15.1

126.2 ± 12.7

DBP (mm Hg), 0 weeks

72.1 ± 12.2

74.4 ± 10.6

DBP (mm Hg), 8 weeks

72.1 ± 11.1

74.9 ± 13.1

HbA1 (%), 0 weeks

7.57 ± 0.77

7.32 ± 0.54

HbA1c (%), 8 weeks

7.41 ± 0.73

7.47 ± 0.67

ΔHbA1c

-0.154 ± 0.32

0.146 ± 0.49

<0.01

Number of drugs

5.3 ± 2.0

6.0 ± 2.9