J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 10, Number 7, July 2018, pages 570-575

Ischemic Modified Albumin Predicts Critical Coronary Artery Disease in Unstable Angina Pectoris and Non-ST-Elevation Myocardial Infarction

Figure 1. IMA cut-off value in diagnosing critical coronary artery disease. Values of 123 or greater predicted critical coronary artery stenosis with a sensitivity of 64.7% and a specificity of 78.6% (area under curve: 0.704).

**Table 1.** Comparison of Demographic Characteristics, IMA, CRP, BNP and Troponin Levels Between Patients With Critical CAD and Non-Critical CAD
	Critical CAD (n = 51)	Non-critical CAD (n = 14)	P (P < 0.05)
BNP: brain natriuretic peptide; CAD: coronary artery disease; CRP: C-reactive protein; IMA: ischemia modified albumin; M: men; W: women. *Age and diastolic blood pressure were significantly higher in the critical CAD group compared to the noncritical CAD group. The comparison of patients with and without critical CAD revealed that IMA and BNP levels were significantly higher in patients with critical CAD.
Age (years)	64 (41-82)	45.5 (30-77 )	0.020*
Gender (n)	18 W, 33 M	7 W, 7 M	0.489
Diabetes mellitus (n)	21	4	0.583
Hypertension (n)	32	8	0.943
Hyperlipidemia (n)	17	3	0.521
Smoking (n)	20	5	0.625
Systolic blood pressure (mm Hg)	130 (100 - 180)	125 (100 - 142)	0.194
Diastolic blood pressure (mm Hg)	80 (50 - 100)	70 (50 - 90)	0.006*
Familial history of CAD (n)	12	5	0.493
Heart rate (beats/min)	83 (59 - 120)	76.5 (57 - 108)	0.155
IMA (ng/mL) (median)	206 (8 - 1,131)	23 (2 - 123)	< 0.001*
CRP (mg/dL)	3.8 (1 - 97)	1.1 (1 - 18.5)	0.076
BNP (pg/mL)	90 (3 - 614.6)	36.4 (7.1 - 121.3)	0.012*
Troponin (ng/mL)	0.03 (0 - 4.1)	0.01 (0.1 - 2.3)	0.632

Table 1. Comparison of Demographic Characteristics, IMA, CRP, BNP and Troponin Levels Between Patients With Critical CAD and Non-Critical CAD

Critical CAD (n = 51)

Non-critical CAD (n = 14)

P (P < 0.05)

BNP: brain natriuretic peptide; CAD: coronary artery disease; CRP: C-reactive protein; IMA: ischemia modified albumin; M: men; W: women. *Age and diastolic blood pressure were significantly higher in the critical CAD group compared to the noncritical CAD group. The comparison of patients with and without critical CAD revealed that IMA and BNP levels were significantly higher in patients with critical CAD.

Age (years)

64 (41-82)

45.5 (30-77 )

0.020*

Gender (n)

18 W, 33 M

7 W, 7 M

0.489

Diabetes mellitus (n)

0.583

Hypertension (n)

0.943

Hyperlipidemia (n)

0.521

Smoking (n)

0.625

Systolic blood pressure (mm Hg)

130 (100 - 180)

125 (100 - 142)

0.194

Diastolic blood pressure (mm Hg)

80 (50 - 100)

70 (50 - 90)

0.006*

Familial history of CAD (n)

0.493

Heart rate (beats/min)

83 (59 - 120)

76.5 (57 - 108)

0.155

IMA (ng/mL) (median)

206 (8 - 1,131)

23 (2 - 123)

< 0.001*

CRP (mg/dL)

3.8 (1 - 97)

1.1 (1 - 18.5)

0.076

BNP (pg/mL)

90 (3 - 614.6)

36.4 (7.1 - 121.3)

0.012*

Troponin (ng/mL)

0.03 (0 - 4.1)

0.01 (0.1 - 2.3)

0.632

**Table 2.** Demographic and Laboratory Characteristics of the Patients According to Gensini Scores
	Low Gensini score (n = 25)	Moderate Gensini score (n = 24)	High Gensini score (n = 16)	P (P < 0.05)
BNP: brain natriuretic peptide; CAD: coronary artery disease; CRP: C-reactive protein; IMA: ischemia modified albumin; LDL: low-density lipoprotein; HDL: high-density lipoprotein; WBC: white blood cell; PLT: platelet; MPV: mean platelet volume; HBG: hemoglobin. *The groups according to the Gensini score level showed that BNP and troponin levels were significantly higher in the high Gensini score group compared to the other groups.
Age (years)	60.0 (30 - 82)	59.5 (45 - 78)	62.8 (44 - 81)	0.386
Gender (n)	13 W, 12 M	6 W, 18 M	6 W, 10 M	0.151
Diabetes mellitus (n)	8	10	7	0.690
Hypertension (n)	15	16	9	0.785
Hyperlipidemia (n)	20	15	10	0.317
Smoking (n)	6	11	8	0.151
Systolic blood pressure (mm Hg)	120 (100 - 160)	130 (100 - 170)	130 (110 - 180)	0.677
Diastolic blood pressure (mm Hg)	80 (50 - 100)	80 (50 - 100)	80 (60 - 100)	0.146
Familial history of CAD (n)	6	8	3	0.561
Heart rate (beats/min)	82.0 (57 - 120)	85.5 (67 - 101)	78.0 (64-102)	0.405
IMA (ng/mL)	101 (2 - 1,256)	225.5 (2 - 841)	218.5 (2 - 1,131)	0.268
CRP(mg/dL)	1.1 (1 - 55)	3.7 (1 - 97)	3.75 (1.1 - 41.2)	0.291
BNP (pg/mL)	33.2 (7 - 238)	87.5 (5 - 615)	137.7 (36 - 496)	0.005*
Troponin (ng/mL)	0.01 (0.002 - 2.6)	0.06 (0.008 - 4.1)	0.25 (0.01 - 2.3)	0.034*
Uric acid (mg/dL)	4.9 (2.9 - 7.3)	6.35 (5 - 9.8)	6.15 (3.9 - 9)	0.106
Fasting blood glucose (mg/dL)	110 (70 - 326)	119 (70 - 1,151)	106 (86 - 374)	0.766
Creatinine (mg/dL)	1 (0.6 - 1.5)	1 (0.8 - 1.5)	1 (0.7 - 1.4)	0.091
LDL (mg/dL)	98 (45 - 159)	111 (60 - 192)	108 (58 - 201)	0.095
HDL (mg/dL)	31 (21 - 85)	31 (18 - 49)	33.5 (22 - 62)	0.816
Triglycerides (mg/dL)	116 (60 - 335)	152.5 (65 - 266)	114.5 (80 - 326)	0.904
Total cholesterol (mg/dL)	154 (89 - 231)	190.5 (106 - 250)	171.5 (93 - 251)	0.082
WBC (1,000/µL)	7.9 (3.8 - 20)	8.3 (3.9 - 17)	8.5 (4 - 12.4)	0.852
PLT (1,000/µL)	233 (124 - 383)	226.5 (129 - 368)	219.5 (127 - 385)	0.808
MPV (fL)	8.2 (6.6 - 9.3)	7.85 (5.8 - 10)	8.2 (6.8 - 9.3)	0.676
HBG (g/dL)	12.1 (9.2 - 15.9)	13.4 (8.2 - 17.5)	12.2 (9.4 - 16.3)	0.203

Table 2. Demographic and Laboratory Characteristics of the Patients According to Gensini Scores

Low Gensini score (n = 25)

Moderate Gensini score (n = 24)

High Gensini score (n = 16)

P (P < 0.05)

BNP: brain natriuretic peptide; CAD: coronary artery disease; CRP: C-reactive protein; IMA: ischemia modified albumin; LDL: low-density lipoprotein; HDL: high-density lipoprotein; WBC: white blood cell; PLT: platelet; MPV: mean platelet volume; HBG: hemoglobin. *The groups according to the Gensini score level showed that BNP and troponin levels were significantly higher in the high Gensini score group compared to the other groups.

Age (years)

60.0 (30 - 82)

59.5 (45 - 78)

62.8 (44 - 81)

0.386

Gender (n)

13 W, 12 M

6 W, 18 M

6 W, 10 M

0.151

Diabetes mellitus (n)

0.690

Hypertension (n)

0.785

Hyperlipidemia (n)

0.317

Smoking (n)

0.151

Systolic blood pressure (mm Hg)

120 (100 - 160)

130 (100 - 170)

130 (110 - 180)

0.677

Diastolic blood pressure (mm Hg)

80 (50 - 100)

80 (60 - 100)

0.146

Familial history of CAD (n)

0.561

Heart rate (beats/min)

82.0 (57 - 120)

85.5 (67 - 101)

78.0 (64-102)

0.405

IMA (ng/mL)

101 (2 - 1,256)

225.5 (2 - 841)

218.5 (2 - 1,131)

0.268

CRP(mg/dL)

1.1 (1 - 55)

3.7 (1 - 97)

3.75 (1.1 - 41.2)

0.291

BNP (pg/mL)

33.2 (7 - 238)

87.5 (5 - 615)

137.7 (36 - 496)

0.005*

Troponin (ng/mL)

0.01 (0.002 - 2.6)

0.06 (0.008 - 4.1)

0.25 (0.01 - 2.3)

0.034*

Uric acid (mg/dL)

4.9 (2.9 - 7.3)

6.35 (5 - 9.8)

6.15 (3.9 - 9)

0.106

Fasting blood glucose (mg/dL)

110 (70 - 326)

119 (70 - 1,151)

106 (86 - 374)

0.766

Creatinine (mg/dL)

1 (0.6 - 1.5)

1 (0.8 - 1.5)

1 (0.7 - 1.4)

0.091

LDL (mg/dL)

98 (45 - 159)

111 (60 - 192)

108 (58 - 201)

0.095

HDL (mg/dL)

31 (21 - 85)

31 (18 - 49)

33.5 (22 - 62)

0.816

Triglycerides (mg/dL)

116 (60 - 335)

152.5 (65 - 266)

114.5 (80 - 326)

0.904

Total cholesterol (mg/dL)

154 (89 - 231)

190.5 (106 - 250)

171.5 (93 - 251)

0.082

WBC (1,000/µL)

7.9 (3.8 - 20)

8.3 (3.9 - 17)

8.5 (4 - 12.4)

0.852

PLT (1,000/µL)

233 (124 - 383)

226.5 (129 - 368)

219.5 (127 - 385)

0.808

MPV (fL)

8.2 (6.6 - 9.3)

7.85 (5.8 - 10)

8.2 (6.8 - 9.3)

0.676

HBG (g/dL)

12.1 (9.2 - 15.9)

13.4 (8.2 - 17.5)

12.2 (9.4 - 16.3)

0.203