J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 9, Number 10, October 2017, pages 860-863

Obstetric Outcomes of Twin Pregnancies in Japanese Women Aged 40 and Older

Tables

**Table 1.** Maternal Characteristics of Twin Pregnancy in Women Aged 25 - 29 (Control) and ≥ 40 Years (Advanced Age)
	Control		Advanced age		P-value
	Number	%	Number	%	P-value
Data are presented as number with percentage or mean ± SD.
Total	536		117
Maternal age at delivery
Range	25 - 29		40 - 45
Average	27.9 ± 0.8		41.9 ± 0.7
Nulliparous	358	67	53	45	< 0.01
Maternal height	156 ± 6		157 ± 7		0.68
Prepregnancy body mass index	22.0 ± 3.5		22.3 ± 3.1		0.55
Body mass index at delivery	27.5 ± 3.7		27.3 ± 3.5		0.48
In vitro fertilization	0	0	38	32	< 0.01
Egg donor	0	0	0	0	1
Fetal reduction	0	0	1	1	0.18
Monochorionic twin pregnancy	204	38	41	35	0.46
Chronic hypertension	0	0	1	1	0.18
Pregestational diabetes	0	0	0	0	1
Low-dose aspirin in pregnancy	0	0	0	0	1
Uterine myoma with a diameter of 4 cm or more	36	7	15	13	0.04

**Table 2.** Obstetric Outcomes of Twin Pregnancy in Women Aged 25 - 29 (Control) and ≥ 40 Years (Advanced Age)
	Control		Advanced age		P-value
	Number	%	Number	%	P-value
Data are presented as number with percentage. HELLP: hemolytic, elevated liver enzymes and low platelet.
Total	536		117
Gestational age at delivery
< 28 weeks	12	2	0	0	0.14
< 32 weeks	40	7	1	1	0.01
< 34 weeks	72	13	16	14	0.95
< 37 weeks	303	57	75	64	0.15
Cesarean delivery
Elective	351	65	80	68	0.59
After labor	42/185	23	11/37	30	0.40
Hypertensive disorder	48	9	17/116	15	0.09
HELLP syndrome	0	0	3	3	< 0.01
Gestational diabetes	8	1	0	0	0.36
Placental abruption	6	1	1	1	1.00
Placenta previa	1	0	0	0	1.00
Either twin fetal demise	0	0	0	0	1.00
At 12 - 21 weeks	0	0	0	0	1.00
At ≥ 22 weeks	3	1	0	0	0.96
Birth weight of smaller twin
< 1,500 g	33/533	6	15	13	0.02
< 2,500 g	476/533	88	112	96	0.04
Birth weight of larger twin
< 1,500 g	70	13	4	3	< 0.01
< 2,500 g	461	86	81	69	< 0.01
Birth weight discordance ≥ 20%	33	6	9	8	0.53
Neonatal outcomes of first twin
Apgar score at 1 min < 7	18	3	0	0	0.06
Apgar score at 5 min < 7	1	0	0	0	1.00
Neonatal outcomes of first twin
Apgar score at 1 min < 7	33/533	16	2	2	0.07
Apgar score at 5 min < 7	1/533	0	0	0	1.00
Postpartum hemorrhage requiring transfusion	8	2	4	4	0.24