J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 9, Number 10, October 2017, pages 879-885

Incretin Kinetics Before and After Miglitol in Japanese Patients With Late Dumping Syndrome

**Table 1.** Clinical Features and Demographic Profile
Patients	Case 1	Case 2	Case 3	Case 4
Sex	Male	Male	Female	Female
Age (years)	73	75	71	83
Height (cm)	165.7	159.4	152.8	155.7
Body weight (kg)	50.5	49.7	43.1	39.6
Body mass index (kg/m²)	18.4	19.7	18.5	16.3
Operation	Total gastrectomy (Rouex-en-Y)	Total gastrectomy (Roux-en-Y)	Total gastrectomy (unknown)	Partial gastrectomy and duodenectomy (unknown)

Table 1. Clinical Features and Demographic Profile

Patients

Case 1

Case 2

Case 3

Case 4

Sex

Male

Female

Age (years)

Height (cm)

165.7

159.4

152.8

155.7

Body weight (kg)

50.5

49.7

43.1

39.6

Body mass index (kg/m²)

18.4

19.7

18.5

16.3

Operation

Total gastrectomy (Rouex-en-Y)

Total gastrectomy (Roux-en-Y)

Total gastrectomy (unknown)

Partial gastrectomy and duodenectomy (unknown)

**Table 2.** Blood Glucose and Insulin Levels in the OGTT Before and After Miglitol
	0 min	30 min	60 min	120 min	180 min
Blood glucose (mg/dL)
OGTT before miglitol
Case 1	104	276	278	154	65
Case 2	88	240	179	116	70
Case 3	89	279	175	46	69
Case 4	81	171	222	114	27
OGTT after miglitol
Case 1	102	229	159	87	87
Case 2	88	191	200	89	57
Case 3	87	168	58	70	80
Case 4	77	147	185	70	55
Insulin (µU/mL)
OGTT before miglitol
Case 1	4.1	66.9	287.7	146.5	13
Case 2	3.6	99.18	84.7	21.5	2.9
Case 3	4.3	88.5	195.9	11	8.6
Case 4	0.8	91.4	119.8	34.3	3
OGTT after miglitol
Case 1	3.1	211.2	70.5	18.6	5.4
Case 2	4.7	238.2	377.5	36.8	6.3
Case 3	1.6	64.1	8.4	2.1	2
Case 4	0.5	63.1	30.7	3.9	1.7
Insulinogenic index
OGTT before miglitol
Case 1	0.37
Case 2	0.63
Case 3	0.44
Case 4	1.01
OGTT after miglitol
Case 1	1.64
Case 2	2.27
Case 3	0.77
Case 4	0.89

Table 2. Blood Glucose and Insulin Levels in the OGTT Before and After Miglitol

0 min

30 min

60 min

120 min

180 min

Blood glucose (mg/dL)

OGTT before miglitol

Case 1

104

276

278

154

Case 2

240

179

116

Case 3

279

175

Case 4

171

222

114

OGTT after miglitol

Case 1

102

229

159

Case 2

191

200

Case 3

168

Case 4

147

185

Insulin (µU/mL)

OGTT before miglitol

Case 1

4.1

66.9

287.7

146.5

Case 2

3.6

99.18

84.7

21.5

2.9

Case 3

4.3

88.5

195.9

8.6

Case 4

0.8

91.4

119.8

34.3

OGTT after miglitol

Case 1

3.1

211.2

70.5

18.6

5.4

Case 2

4.7

238.2

377.5

36.8

6.3

Case 3

1.6

64.1

8.4

2.1

Case 4

0.5

63.1

30.7

3.9

1.7

Insulinogenic index

OGTT before miglitol

Case 1

0.37

Case 2

0.63

Case 3

0.44

Case 4

1.01

OGTT after miglitol

Case 1

1.64

Case 2

2.27

Case 3

0.77

Case 4

0.89

**Table 3.** Total GIP, Active GLP-1 and Glucagon in the OGTT Before and After Miglitol
	0 min	30 min	60 min	120 min	180 min
Active GLP-1 (pmol/mL)
OGTT before miglitol
Case 1	2	38.7	19.6	10.9	2.6
Case 2	3.8	88.9	36	16.1	3.8
Case 3	2	50.6	15.2	14.2	3.7
Case 4	2	54.9	39.2	7.2	2
OGTT after miglitol
Case 1	2	42.4	7.8	16.7	3.8
Case 2	2	98.8	18.7	7	4.6
Case 3	2	19.5	4.1	3.3	2.7
Case 4	2	12.9	5	3	3.1
Total GIP (pg/mL)
OGTT before miglitol
Case 1	48	357	213	82.5	69.2
Case 2	64.7	598	214	134	81.5
Case 3	58.5	520	210	123	81.5
Case 4	41.8	530	437	189	71
OGTT after miglitol
Case 1	52.2	278	132	71.9	64.6
Case 2	59.5	476	255	125	79.6
Case 3	66.9	277	151	87.3	63.5
Case 4	33.7	262	213	53.7	32.3
Glucagon (pg/mL)
OGTT before miglitol
Case 1	63	151	127	106	122
Case 2	78	130	136	140	147
Case 3	66	133	97	97	107
Case 4	75	92	103	96	90
OGTT after miglitol
Case 1	54	126	115	108	111
Case 2	101	150	156	130	150
Case 3	54	69	67	75	64
Case 4	57	82	72	64	65

Table 3. Total GIP, Active GLP-1 and Glucagon in the OGTT Before and After Miglitol

0 min

30 min

60 min

120 min

180 min

Active GLP-1 (pmol/mL)

OGTT before miglitol

Case 1

38.7

19.6

10.9

2.6

Case 2

3.8

88.9

16.1

3.8

Case 3

50.6

15.2

14.2

3.7

Case 4

54.9

39.2

7.2

OGTT after miglitol

Case 1

42.4

7.8

16.7

3.8

Case 2

98.8

18.7

4.6

Case 3

19.5

4.1

3.3

2.7

Case 4

12.9

3.1

Total GIP (pg/mL)

OGTT before miglitol

Case 1

357

213

82.5

69.2

Case 2

64.7

598

214

134

81.5

Case 3

58.5

520

210

123

81.5

Case 4

41.8

530

437

189

OGTT after miglitol

Case 1

52.2

278

132

71.9

64.6

Case 2

59.5

476

255

125

79.6

Case 3

66.9

277

151

87.3

63.5

Case 4

33.7

262

213

53.7

32.3

Glucagon (pg/mL)

OGTT before miglitol

Case 1

151

127

106

122

Case 2

130

136

140

147

Case 3

133

107

Case 4

103

OGTT after miglitol

Case 1

126

115

108

111

Case 2

101

150

156

130

150

Case 3

Case 4

**Table 4.** Results of CGM Before and After Miglitol
Patients	Case 1	Case 2	Case 3
Before
Mean (mg/dL)	153	94	97
Maximum (mg/dL)	374	271	220
Minimum (mg/dL)	62	40	59
SD (mg/dL)	73	49	28
After
Mean (mg/dL)	98	105	81
Maximum (mg/dL)	142	231	116
Minimum (mg/dL)	65	68	66
SD (mg/dL)	20	33	10

Table 4. Results of CGM Before and After Miglitol

Patients

Case 1

Case 2

Case 3

Before

Mean (mg/dL)

153

Maximum (mg/dL)

374

271

220

Minimum (mg/dL)

SD (mg/dL)

After

Mean (mg/dL)

105

Maximum (mg/dL)

142

231

116

Minimum (mg/dL)

SD (mg/dL)