J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 8, Number 11, November 2016, pages 793-796

LDLR C1725T Gene Polymorphism Frequency in Type 2 Diabetes Mellitus Patients With Dyslipidemia

Tables

**Table 1.** Characteristics and the Biochemical Parameters of Diabetic Dyslipidemia Patients and Control Group
	Diabetic dyslipidemia (mean ± SD) (n = 217)	Control (mean ± SD) (n = 212)	P-value
HDL: high-density lipoproteins; LDL: low-density lipoproteins.
Gender (female/male)	133/84	122/90	NS
Age (years)	53.2 ± 9.8	52.8 ± 9.2	NS
Fasting glucose (mg/dL)	161.9 ± 72.5	87.7 ± 11.6	< 0.001
Total cholesterol (mg/dL)	219.3 ± 61.8	178.2 ± 20.7	< 0.001
Triglycerides (mg/dL)	231.6 ± 255.8	109.5 ± 25.9	< 0.001
HDL cholesterol (mg/dL)	48.5 ± 13.6	63 ± 8.9	< 0.001
LDL cholesterol (mg/dL)	131.6 ± 42.3	117 ± 17.9
Lipid-lowering therapy (%)	68	-
Oral antidiabetic therapy (%)	20	-
Insulin therapy (%)	29	-

**Table 2.** Genotype Distribution and Allele Frequency of LDLR C1725T (rs1799898) Gene Polymorphisms in Diabetic Dyslipidemia Patients and the Control Group
Gene/SNP	Genotypes haplotype	Patients, n (%)	Control, n (%)	P-value
LDLR C1725T (rs1799898)	CC	143 (66.2)	142 (67.0)	0.256
	CT	70 (32.4)	62 (29.2)
	TT	3 (1.4)	8 (3.8)
	C	356	346
	T	76	78

**Table 3.** Genotype Distribution of LDLR C1725T (rs1799898) Gene Polymorphisms in Type 2 Diabetic Dyslipidemia Patients and Type 2 Diabetic Dyslipidemia Patients With MI
Gene/SNP	Genotypes haplotype	Patients, n (%)	Patients with MI, n (%)	P-value
LDLR C1725T (rs1799898)	CC	124 (66.0)	19 (67.9)	> 0.05
	CT	61 (32.4)	9 (32.1)
	TT	3 (1.6)	0 (0)