Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
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Case Report

Volume 8, Number 7, July 2016, pages 555-559

Systemic Lupus Erythematosus With Acute Inflammatory Demyelinating Polyneuropathy: A Case Report and Review of the Literature


Figure 1.
Figure 1. Histologic features of section of kidney biopsy. Glomerular mesangial proliferation with focal endothelial cell proliferation. (A) H&E, × 400; (B) PASM, × 400; (C) Masson, × 400; (D) Gomori methenamine silver (GMS), × 400.


Table 1. Electrophysiological Findings
Lat (SD), msAmp (SD), mVCV (SD), m/sAmp (SD), %
Motor nerve
  Right medianus
    Wrist-APB4.5 (3.9)0.2 (-2.7)
  Left ulnaris
    Wrist-ADM3.8 (-6.2)0.1 (-4.5)
    Ab elbow-wrist8.50.647.8 (-1.7)435 (52)
  Right tibialis
    Ankle-AHB9.4 (15.70.1
  Left tibialis
    Ankle-AHB9.0 (14.6)0.0
  Right peroneus
    Ankle-EDB7.9 (8.3)0.2 (-2.1)
    CF down-ankle17.00.234.23
  Left peroneus
    Ankle-EDB9.0 (9.8)0.1 (-2.1)
    CF down-ankle18.70.332.4415
Sensory nerve
  Right medianus
    Dig II-wrist2.6 (-0.7)1653.7
  Left ulnaris
    Dig V-wrist2.8 (0.1)1246.5
  Right peroneus super
    Ankle-foreleg4.14.035.0 (-3.2)
  Left peroneus super
    Ankle-foreleg3.95.933.4 (-3.6)


Table 2. Previous Reports About GBS or AIDP With SLE
AuthorAge/sexGBS and SLEOrgan involvementAuto-Ab(+)Treatment (effect +, -)
PE: plasma exchange; IVIG: intravenous immunoglobulin; ANA: antinuclear antibody; anti-dsDNA: anti-double-stranded DNA; anti-SS-A: anti-Ro antibodies; anti-SS-B: anti-La antibodies; AHA: anti-histone antibodies; ACA: anti-cardiolipin antibodies; PNS: peripheral nervous system; anti-Smith: anti-Smith antibodies.
Hsu et al [18]28/FEarlyPNS, pleurisy, lymphopeniaANA, anti-dsDNA, anti-Ro/SS-A, anti-La/SS-BPrednisolone, PE, (+)
Chaudhuri et al [20]40/MEarlyPNA, lymphopenia, seizure, membranous glomerulonephritisANA, anti-dsDNAPrednisolone, cyclophosphamide, PE, (+)
Santiago-Casas et al [22]20/FEarlyPNA, lymphopenia, proteinuriaANA, anti-dsDNACyclophosphamide, glucocorticoids, PE, IVIG, (+)
Santiago-Casas et al [22]34/FEarlyPNS, arthritis, lymphopeniaANA, anti-dsDNAGlucocorticoids, IVIG, cyclophosphamide, (+)
Miyagawa et al [13]9/FLatePNS, chilblain or erythema multiforme, oral ulcersANA, anti-dsDNA, anti-Ro/SS-A, anti-La/SS-BCorticosteroids, PE, IVIG, (+)
Robson et al [23]33/FEarlyHemolytic anemia, thrombocytopenia, retinal vasculitis, PNS, CNSANA, anti-dsDNAGlucocorticoids, cyclophosphamide, (+)
Vaidya et al [16]23/MEarlyPNS, WHO class V lupus nephropathyANA, anti-dsDNAGlucocorticoids, cyclophosphamide, PE, (+)
Millette et al [21]23/FEarlyPNS, cranial nerveANA, anti-dsDNA, anti-Smith, anti-RNPGlucocorticoids, (+)
Okoh et al [8]41/FEarlyLeukopenia, pericardial and pleural effusions, proteinuria, and hematuriaANA, anti-dsDNA, anti-SmithCyclophosphamide, glucocorticoids, PE, IVIG, mycophenolate mofetil, (+)
van Laarhoven et al [19]20/FEarlyFacial exanthema pleural and pericardial, proteinuria, autoimmune hemolytic anemiaANA, anti-Smith, anti-RNPIVIG, cyclophosphamide, glucocorticoids, (+)
Rajadhyaksha et al [17]30/FEarlyOral ulcers, arthralgias, bulbar palsy, cranial nerve, class II mesangio proliferative lupus nephritis nerveANA, anti-dsDNA, anti-Smith, GT1a, GQ1b, GM1bIVIG, glucocorticoids, (+)
Ha-Ou-Nou et al [11]44/MEarlyLymphopenia, proteinuria, thrombocytopeniaanti-dsDNACorticosteroids, IVIG, (-)
Stahl et al [14]56/FEarlyThrombocytopenia, stomatitis, hair loss, arthritisANA, AHAIVIG, cyclophosphamide, corticosteroids, (-)
Lewis and Gibson [12]21/MLateArthritis, pleuro-pericarditis, proteinuriaANA, anti-dsDNA, anti-RNP, ACACyclophosphamide, IVIG, prednisolone, (+)
Yildiz et al [9]47/FLateDiscoid rash, photosensitivity, oral ulcers, leucopenia, lymphopeniaANACorticosteroid, cyclophosphamide, (+)
Matsuki et al [15]61/FEarlyArthritis, oral ulcers, pericarditis, lymphopeniaANA, anti-dsDNA, anti-Ro/SS-A, anti-GMlMethylprednisolone, mizoribine, immunoadsorption, PE, (+)