J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 8, Number 6, June 2016, pages 431-436

Associations of Apolipoprotein A, High-Sensitivity C-Reactive Protein and Fasting Plasma Insulin in Obese Children With and Without Family History of Cardiovascular Disease

**Table 1.** Basic Characteristics Between Boys and Girls (n = 68)
	Boys (N = 28), mean ± SD	Girls (N = 40), mean ± SD	P-value
P < 0.05. ^aMann-Whitney test, all other t-test.
Age (years)	9.78 ± 3.48	9.48 ± 2.71	0.684
Height (cm)	1.41 ± 0.19	1.39 ± 0.15	0.479
Weight (kg)^a	50.2 ± 26.4	43 ± 21.9	0.223
BMI (kg/m²)^a	23.67 ± 7.4	21.2 ± 6.6	0.182
SBP (mm Hg)	59.72 ± 7.8	50.3 ± 29.2	0.185
DBP (mm Hg)	57.32 ± 8.8	49.2 ± 25.4	0.224
TC (mg/dL)^a	162.4 ± 45.5	162.8 ± 29.7	0.974
TG (mg/dL)^a	78.5 ± 39.5	83.9 ± 45	0.605
HDL (mg/dL)^a	48.3 ± 14.7	52.3 ± 16.8	0.307
LDL (mg/dL)	92 ± 24.1	95 ± 22.8	0.543
ApoA (mg/dL)	133.53 ± 0	140.3 ± 27.1	0.330
ApoB (mg/dL)^a	69.9 ± 22.2	63.6 ± 15.1	0.165

Table 1. Basic Characteristics Between Boys and Girls (n = 68)

Boys (N = 28), mean ± SD

Girls (N = 40), mean ± SD

P-value

P < 0.05. ^aMann-Whitney test, all other t-test.

Age (years)

9.78 ± 3.48

9.48 ± 2.71

0.684

Height (cm)

1.41 ± 0.19

1.39 ± 0.15

0.479

Weight (kg)^a

50.2 ± 26.4

43 ± 21.9

0.223

BMI (kg/m²)^a

23.67 ± 7.4

21.2 ± 6.6

0.182

SBP (mm Hg)

59.72 ± 7.8

50.3 ± 29.2

0.185

DBP (mm Hg)

57.32 ± 8.8

49.2 ± 25.4

0.224

TC (mg/dL)^a

162.4 ± 45.5

162.8 ± 29.7

0.974

TG (mg/dL)^a

78.5 ± 39.5

83.9 ± 45

0.605

HDL (mg/dL)^a

48.3 ± 14.7

52.3 ± 16.8

0.307

LDL (mg/dL)

92 ± 24.1

95 ± 22.8

0.543

ApoA (mg/dL)

133.53 ± 0

140.3 ± 27.1

0.330

ApoB (mg/dL)^a

69.9 ± 22.2

63.6 ± 15.1

0.165

**Table 2.** Comparison of Normal and Obese Groups With and Without FH of CVD
Variables	Normal	Obese
P < 0.05. ^aDistribution not normal (median, min. - max.). ^bData presented as log (geometric mean × geometric SD). Statistically significant difference between obese and normal group. *Statistically significant difference between obese and normal group with PFH.
SBP	54 ± 23.9	38.9 ± 26.6	42.5 ± 26.4	68.5 ± 24.9	63.2 ± 28.2	65.5 ± 26.6*
DBP	47.5 ± 30.1	51.2 ± 30.4	50.3 ± 29.9	53.3 ± 29.9	56 ± 19.9	54.9 ± 24.3
TC	167 ± 33	166 ± 30	167 ± 31	191 ± 18	178 ± 24	181 ± 24.5*
TG	59.5 ± 22.5	73.8 ± 42.2	70.4 ± 38.7	88 ± 44.5	95.9 ± 44.2	92.5 ± 43.8*
HDL	64.9 ± 19.3	54.4 ± 17.5	56.9 ± 18.2	41.9 ± 10	46.5 ± 10.6	44.5 ± 10.5*
LDL	88.8 ± 29.5	92 ± 43.4	90.4 ± 40.6	104.4 ± 21	99.5 ± 23	101 ± 22.9
ApoA	159.9 ± 25	141 ± 31.6	145.6 ± 31	135.4 ± 21.8**	121 ± 23.6	129 ± 23.3*
ApoB	61 ± 15.6	67.3 ± 19.3	65.9 ± 18.5	66.6 ± 22.8	66.7 ± 15.9	66.7 ± 18.9
Lp(a)^a	20 (3.4 - 113.9)	21.2 (2 - 200)	21.2 (2 - 200)	16.5 (4.1 - 106)	16.5 (4.4 - 87)	16.5 (4.1 - 106)
hsCRP^a	0.11 (0.01 - 2.54)	0.08 (0.01 - 2.6)	0.08 (0.01 - 2.6)	0.78 (0.03 - 2.8)	0.73 (0.02 - 2.7)	0.75 (0.02 - 2.8)*
FBG	84.4 ± 12	88 ± 7.7	87 ± 8.9	87 ± 8.7	89.5 ± 8	88.4 ± 8.4
FPI^a	6.6 (1.1 - 35.6)	8.6 (2.9 - 159)	8.2 (1.1 - 159)	16 (4.5 - 42)**	11.8 (0.2 - 31)	12.8 (0.2 - 42)*
HOMA-IR^b	0.95 × 2.28 (0.35 - 4.35)	1.06 × 1.68 (0.38 - 3.24)	1.03 × 1.81 (0.35 - 4.35)	1.8 × 1.9 (0.58 - 5.24)	1.43 × 1.77 (0.37 - 3.83)	1.58 × 1.83* (0.37 - 5.24)

Table 2. Comparison of Normal and Obese Groups With and Without FH of CVD

Variables

Normal

Obese

PFH (n = 8)

NFH (n = 25)

Total (n = 33)

PFH (n = 15)

NFH (n = 20)

Total (n = 35)

P < 0.05. ^aDistribution not normal (median, min. - max.). ^bData presented as log (geometric mean × geometric SD). *Statistically significant difference between obese and normal group. **Statistically significant difference between obese and normal group with PFH.

SBP

54 ± 23.9

38.9 ± 26.6

42.5 ± 26.4

68.5 ± 24.9

63.2 ± 28.2

65.5 ± 26.6*

DBP

47.5 ± 30.1

51.2 ± 30.4

50.3 ± 29.9

53.3 ± 29.9

56 ± 19.9

54.9 ± 24.3

167 ± 33

166 ± 30

167 ± 31

191 ± 18

178 ± 24

181 ± 24.5*

59.5 ± 22.5

73.8 ± 42.2

70.4 ± 38.7

88 ± 44.5

95.9 ± 44.2

92.5 ± 43.8*

HDL

64.9 ± 19.3

54.4 ± 17.5

56.9 ± 18.2

41.9 ± 10

46.5 ± 10.6

44.5 ± 10.5*

LDL

88.8 ± 29.5

92 ± 43.4

90.4 ± 40.6

104.4 ± 21

99.5 ± 23

101 ± 22.9

ApoA

159.9 ± 25

141 ± 31.6

145.6 ± 31

135.4 ± 21.8**

121 ± 23.6

129 ± 23.3*

ApoB

61 ± 15.6

67.3 ± 19.3

65.9 ± 18.5

66.6 ± 22.8

66.7 ± 15.9

66.7 ± 18.9

Lp(a)^a

20 (3.4 - 113.9)

21.2 (2 - 200)

16.5 (4.1 - 106)

16.5 (4.4 - 87)

16.5 (4.1 - 106)

hsCRP^a

0.11 (0.01 - 2.54)

0.08 (0.01 - 2.6)

0.78 (0.03 - 2.8)

0.73 (0.02 - 2.7)

0.75 (0.02 - 2.8)*

FBG

84.4 ± 12

88 ± 7.7

87 ± 8.9

87 ± 8.7

89.5 ± 8

88.4 ± 8.4

FPI^a

6.6 (1.1 - 35.6)

8.6 (2.9 - 159)

8.2 (1.1 - 159)

16 (4.5 - 42)**

11.8 (0.2 - 31)

12.8 (0.2 - 42)*

HOMA-IR^b

0.95 × 2.28 (0.35 - 4.35)

1.06 × 1.68 (0.38 - 3.24)

1.03 × 1.81 (0.35 - 4.35)

1.8 × 1.9 (0.58 - 5.24)

1.43 × 1.77 (0.37 - 3.83)

1.58 × 1.83* (0.37 - 5.24)

**Table 3.** Univariate Logistic Regression Analysis Between Cardiometabolic Risk Factor and Family History of CVD
	Univariate logistic regression results*
*P < 0.05.
SBP (mm Hg)	1.018	0.999 - 1.037	0.064	0.13/0.93
TC (mg/dL)	1.983	1.965 - 2.001	0.070	0.13/0.96
TG (mg/dL)	0.997	0.985 - 1.009	0.624	0.00/1.00
HDL (mg/dL)	0.996	0.965 - 1.028	0.801	0.00/1.00
ApoA (mg/dL)	0.995	0.978 - 1.013	0.603	0.00/1.00
hsCRP	1.367	0.689 - 2.715	0.371	0.00/1.00
FPI (mIU/mL)	1.058	0.993 - 1.127	0.080	0.17/0.94
HOMA-IR	1.570	0.941 - 2.619	0.084	0.17/0.94

Table 3. Univariate Logistic Regression Analysis Between Cardiometabolic Risk Factor and Family History of CVD

Univariate logistic regression results*

95% CI

P-value

Sensitivity/specificity

*P < 0.05.

SBP (mm Hg)

1.018

0.999 - 1.037

0.064

0.13/0.93

TC (mg/dL)

1.983

1.965 - 2.001

0.070

0.13/0.96

TG (mg/dL)

0.997

0.985 - 1.009

0.624

0.00/1.00

HDL (mg/dL)

0.996

0.965 - 1.028

0.801

0.00/1.00

ApoA (mg/dL)

0.995

0.978 - 1.013

0.603

0.00/1.00

hsCRP

1.367

0.689 - 2.715

0.371

0.00/1.00

FPI (mIU/mL)

1.058

0.993 - 1.127

0.080

0.17/0.94

HOMA-IR

1.570

0.941 - 2.619

0.084

0.17/0.94

**Table 4.** Logistic Regression Analysis Between Cardiometabolic Risk Factor and Obesity
	Multivariate logistic regression analysis
*P < 0.05.
SBP (mm Hg)	1.045	1.016 - 1.074	0.002*	0.13/0.93
TC (mg/dL)	1.965	1.935 - 2.970	0.031*	0.13/0.96
TG (mg/dL)	0.997	0.985 - 1.009	0.624	0.00/1.00
HDL (mg/dL)	0.996	0.965 - 1.028	0.801	0.00/1.00
ApoA (mg/dL)	0.995	0.978 - 1.013	0.603	0.00/1.00
hsCRP	2.92	0.966 - 8.828	0.058	0.00/1.00
FPI (mIU/mL)	1.058	0.993 - 1.127	0.080	0.17/0.94
HOMA-IR	1.570	0.941 - 2.619	0.084	0.17/0.94

Table 4. Logistic Regression Analysis Between Cardiometabolic Risk Factor and Obesity

Multivariate logistic regression analysis

95% CI

P-value

Sensitivity/specificity

*P < 0.05.

SBP (mm Hg)

1.045

1.016 - 1.074

0.002*

0.13/0.93

TC (mg/dL)

1.965

1.935 - 2.970

0.031*

0.13/0.96

TG (mg/dL)

0.997

0.985 - 1.009

0.624

0.00/1.00

HDL (mg/dL)

0.996

0.965 - 1.028

0.801

0.00/1.00

ApoA (mg/dL)

0.995

0.978 - 1.013

0.603

0.00/1.00

hsCRP

2.92

0.966 - 8.828

0.058

0.00/1.00

FPI (mIU/mL)

1.058

0.993 - 1.127

0.080

0.17/0.94

HOMA-IR

1.570

0.941 - 2.619

0.084

0.17/0.94