J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 2, Number 3, June 2010, pages 112-116

Implementation of Screening for Toxoplasma gondii Infection in Pregnancy

**Table 1.** Prevalence of Anti-Toxoplasma Antibodies by Trimester of First Screening
	I trimester (group 1)	II trimester (group 2)	III trimester (group 3)	Total
CI: Confidence Interval
IgG neg/IgM neg	2975	75.3 (73.95-76.65)	386	89.6 (86.72-92.48)	273	86.9 (83.17-90.63)	3634	77.4 (76.20-78.60)
IgG pos/IgM neg	893	22.6 (21.29-23.90)	44	10.2 (7.34-13.06)	37	11.8 (8.23-15.37)	974	20.7 (19.54-21.86)
IgG neg/IgM pos	12	0.3 (0.13-0.47)	0	0 (0.00-0.00)	2	0.6 (0.00-1.45)	14	0.3 (0.14-0.46)
IgG pos/IgM pos	69	1.7 (1.30-2.10)	1	0.2 (0.00-0.62)	2	0.6 (0.00-1.45)	72	1.5 (1.15-1.85)
Total	3949		431		314		4694

Table 1. Prevalence of Anti-Toxoplasma Antibodies by Trimester of First Screening

I trimester
(group 1)

II trimester
(group 2)

III trimester
(group 3)

Total

Anti-Toxoplasma antibodies

No.

% (95% CI)

No.

% (95% CI)

No.

% (95% CI)

No.

% (95% CI)

CI: Confidence Interval

IgG neg/IgM neg

2975

75.3
(73.95-76.65)

386

89.6
(86.72-92.48)

273

86.9
(83.17-90.63)

3634

77.4
(76.20-78.60)

IgG pos/IgM neg

893

22.6
(21.29-23.90)

10.2
(7.34-13.06)

11.8
(8.23-15.37)

974

20.7
(19.54-21.86)

IgG neg/IgM pos

0.3
(0.13-0.47)

0
(0.00-0.00)

0.6
(0.00-1.45)

0.3
(0.14-0.46)

IgG pos/IgM pos

1.7
(1.30-2.10)

0.2
(0.00-0.62)

0.6
(0.00-1.45)

1.5
(1.15-1.85)

Total

3949

431

314

4694

**Table 2.** Average and Total Number of Screenings of Pregnant Seronegative Women by the Trimester of the First Screening
Trimester of first screening	No. of seronegative women	Average number of screenings(range)	No. of screenings
1	2975	4.1 (1 - 10)	313 (10.5%)	1415 (47.6%)	1247 (41.9%)
2	386	2.3 (1 - 6)	118 (30.6%)	247 (64.0%)	21 (5.4%)
3	273	1.2 (1 - 3)	230 (84.2%)	43 (15.8%)	-
Total	3634	3.7 (1 - 10)	661 (18.2%)	1705 (46.9%)	1268 (34.9%)

Table 2. Average and Total Number of Screenings of Pregnant Seronegative Women by the Trimester of the First Screening

Trimester of first screening

No. of seronegative women

Average number of screenings(range)

No. of screenings

2 - 4

≥ 5

2975

4.1 (1 - 10)

313 (10.5%)

1415 (47.6%)

1247 (41.9%)

386

2.3 (1 - 6)

118 (30.6%)

247 (64.0%)

21 (5.4%)

273

1.2 (1 - 3)

230 (84.2%)

43 (15.8%)

Total

3634

3.7 (1 - 10)

661 (18.2%)

1705 (46.9%)

1268 (34.9%)

**Table 3.** Screenings of Seronegative Women by Trimester of Pregnancy
Screenings	No. of women	% (95% CI)
CI: Confidence Interval
Only I trimester	353	9.7 (8.74 - 10.66)
I trimester + II trimester	300	8.3 (7.40 - 9.20)
I trimester + II trimester + III trimester	2181	60.0 (58.41 - 61.59)
I trimester + III trimester	141	3.9 (3.27 - 4.53)
Only II trimester	138	3.8 (3.18 - 4.42)
II trimester + III trimester	248	6.8 (5.98 - 7.62)
Only III trimester	273	7.5 (6.64 - 8.36)
Total	3634

Table 3. Screenings of Seronegative Women by Trimester of Pregnancy

Screenings

No. of women

% (95% CI)

CI: Confidence Interval

Only I trimester

353

9.7 (8.74 - 10.66)

I trimester + II trimester

300

8.3 (7.40 - 9.20)

I trimester + II trimester + III trimester

2181

60.0 (58.41 - 61.59)

I trimester + III trimester

141

3.9 (3.27 - 4.53)

Only II trimester

138

3.8 (3.18 - 4.42)

II trimester + III trimester

248

6.8 (5.98 - 7.62)

Only III trimester

273

7.5 (6.64 - 8.36)

Total

3634

**Table 4.** Cases of Seroconversion by Week of Pregnancy
	Anti-Toxoplasma IgM antibodies
1	Neg	Neg	-	Neg	Pos	-	-
2	Neg	Neg	Neg	-	-	Pos	-
3	Neg	Neg	-	-	-	-	Pos

Table 4. Cases of Seroconversion by Week of Pregnancy

Anti-Toxoplasma IgM antibodies

Weeks of pregnancy

Case

Neg

Pos

Neg

Pos

Neg

Pos

**Table 5.** Primary Infections by the Trimester in Which IgM Was Detected
	I trimester	II trimester	III trimester	Total
seroconversion*two seroconversions
IgM+ IgG+ (low or borderline avidity)	9 (81.8%)	1 (9.1%)	1 (9.1%)*	11
IgM+ IgG-	3 (50%)	0	3 (50%)**	6
Total	12 (70.6%)	1 (5.9%)	4 (23.5%)	17

Table 5. Primary Infections by the Trimester in Which IgM Was Detected

I trimester

II trimester

III trimester

Total

*seroconversion**two seroconversions

IgM+ IgG+ (low or borderline avidity)

9 (81.8%)

1 (9.1%)

1 (9.1%)*

IgM+ IgG-

3 (50%)

3 (50%)**

Total

12 (70.6%)

1 (5.9%)

4 (23.5%)