J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 1, Number 3, August 2009, pages 150-157

Malondialdehyde and Antioxidant Enzymes in Maternal and Cord Blood, and their Correlation in Normotensive and Preeclamptic Women

**Table 1.** Demographic and clinical characteristics of normotensive (control) and severe preeclamptic subjects
Parameters	Normotensive control group	Severely preeclamptic group	P*-value
Values are expressed as mean ± SD; BMI- body mass index; BP- blood pressure, P*= Two-Samples t-test probability
Number of maternal/neonatal pairs	23	23
Maternal age (years)	29.1 ± 6.9	26.8 ± 7.2	0.275
BMI at delivery (kg/m² )	22.1 ± 2.5	21.4 ± 2.8	0.376
Gestational age (weeks)	33.8 ± 3.9	32.2 ± 4.8	0.221
BP at delivery, systolic (mm/Hg)	109.8 ± 12.9	164.5 ± 13.6	<0.0001
BP at delivery, diastolic (mm/Hg)	65.6 ± 11.4	111.4 ± 14.2	<0.0001
Pulse rate (beats/min)	71.4 ± 1.6	70.8 ± 2.4	0.324
Proteinuria (g/day)	Nil	1.24 ± 0.86	/
Edema	Nil	++ in all cases	/

Table 1. Demographic and clinical characteristics of normotensive (control) and severe preeclamptic subjects

Parameters

Normotensive control group

Severely preeclamptic group

P*-value

Values are expressed as mean ± SD; BMI- body mass index; BP- blood pressure, P*= Two-Samples t-test probability

Number of maternal/neonatal pairs

Maternal age (years)

29.1 ± 6.9

26.8 ± 7.2

0.275

BMI at delivery (kg/m² )

22.1 ± 2.5

21.4 ± 2.8

0.376

Gestational age (weeks)

33.8 ± 3.9

32.2 ± 4.8

0.221

BP at delivery, systolic (mm/Hg)

109.8 ± 12.9

164.5 ± 13.6

<0.0001

BP at delivery, diastolic (mm/Hg)

65.6 ± 11.4

111.4 ± 14.2

<0.0001

Pulse rate (beats/min)

71.4 ± 1.6

70.8 ± 2.4

0.324

Proteinuria (g/day)

Nil

1.24 ± 0.86

Edema

Nil

++ in all cases

**Table 2.** Concentrations of malondialdehyde and activities of various antioxidant enzymes in pair-matched normotensive (control) and severely preeclamptic maternal and cord blood
Parameters	Normotensive maternal (n = 23)	Normotensive cord (n = 23)	preeclamptic maternal (n = 23)	preeclamptic cord (n = 23)
Values are expressed as mean ± SD; Cl* = 95% Confidence Interval for mean
Malondialdehyde (MDA) (nmol/gHb)	9.02 ± 2.36 (Cl*: 8.008 to 10.04)	7.36 ± 1.62 (Cl*: 6.66 to 8.06)	11.98 ± 1.83 (Cl*: 11.19 to 12.77)	8.02 ± 1.05 (Cl*: 7.56 to 8.47)
Superoxide dismutase (U/gHb)	1135.95 ± 100.28 (Cl*: 1092.58 to 1179.32)	1235.17 ± 119.07 (Cl*: 1183.68 to 1286.66)	921.92 ± 117.54 (Cl*: 871.09 to 972.74)	842.16 ± 81.24 (Cl*: 807.03 to 877.29)
Glutathione peroxidase (U/gHb)	15.21 ± 3.04 (Cl*: 13.9 to 16.53)	17.71 ± 2.27 (Cl*: 16.73 to 18.69)	13.92 ± 1.36 (Cl*: 13.33 to 14.51)	12.95 ± 1.89 (Cl*: 12.14 to 13.77)
Glutathione reductase (U/gHb)	11.24 ± 3.03 (Cl*: 9.93 to 12.54)	10.98 ± 2.90 (Cl*: 9.97 to 12.23)	8.98 ± 2.44 (Cl*: 7.93 to 10.04)	8.85 ± 2.46 (Cl*: 7.79 to 9.92)
Catalase (kU/gHb)	98.21 ± 21.17 (Cl*: 89.05 to 107.36)	118.80 ± 25.81 (Cl*: 107.64 to 129.96)	124.70 ± 17.48 (Cl*: 117.14 to 132.26)	144.8 ± 34.99 (Cl*: 129.67 to 159.93)

Table 2. Concentrations of malondialdehyde and activities of various antioxidant enzymes in pair-matched normotensive (control) and severely preeclamptic maternal and cord blood

Parameters

Normotensive maternal
(n = 23)

Normotensive cord
(n = 23)

preeclamptic maternal
(n = 23)

preeclamptic cord
(n = 23)

Values are expressed as mean ± SD; Cl* = 95% Confidence Interval for mean

Malondialdehyde (MDA)
(nmol/gHb)

9.02 ± 2.36
(Cl*: 8.008 to 10.04)

7.36 ± 1.62
(Cl*: 6.66 to 8.06)

11.98 ± 1.83
(Cl*: 11.19 to 12.77)

8.02 ± 1.05
(Cl*: 7.56 to 8.47)

Superoxide dismutase
(U/gHb)

1135.95 ± 100.28
(Cl*: 1092.58 to 1179.32)

1235.17 ± 119.07
(Cl*: 1183.68 to 1286.66)

921.92 ± 117.54
(Cl*: 871.09 to 972.74)

842.16 ± 81.24
(Cl*: 807.03 to 877.29)

Glutathione peroxidase
(U/gHb)

15.21 ± 3.04
(Cl*: 13.9 to 16.53)

17.71 ± 2.27
(Cl*: 16.73 to 18.69)

13.92 ± 1.36
(Cl*: 13.33 to 14.51)

12.95 ± 1.89
(Cl*: 12.14 to 13.77)

Glutathione reductase
(U/gHb)

11.24 ± 3.03
(Cl*: 9.93 to 12.54)

10.98 ± 2.90
(Cl*: 9.97 to 12.23)

8.98 ± 2.44
(Cl*: 7.93 to 10.04)

8.85 ± 2.46
(Cl*: 7.79 to 9.92)

Catalase (kU/gHb)

98.21 ± 21.17
(Cl*: 89.05 to 107.36)

118.80 ± 25.81
(Cl*: 107.64 to 129.96)

124.70 ± 17.48
(Cl*: 117.14 to 132.26)

144.8 ± 34.99
(Cl*: 129.67 to 159.93)