| Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc |
| Journal website http://www.jocmr.org |
Review
Volume 6, Number 2, April 2014, pages 75-85
Levosimendan in Critical Illness: A Literature Review
Table
| Study | Dose bolus | Dose infusion | Duration | Major adverse effects |
|---|---|---|---|---|
| Aidonidis et al. Cardiol Res Pract. 2011 [35] | 0 | 0.05 - 0.2 µg/kg/min | 72 h | No discontinuations due to adverse effects, two patients died of advanced heart failure. |
| Follath et al. Lancet. 2002 [38] | 24 µg/kg | 0.1 µg/kg/min | 24 h | Hypotension, headache, hypokalemia |
| Kivikko et al. J Clin Pharmacol. 2002 [37] | 0.05 - 0.1 µg/kg/min | 7 days | No major adverse effects, no premature discontinuations | |
| Moiseyev et al. Eur Heart J. 2002 [32] | 6, 12, 24 µg/kg | 0.1 - 0.4 µg/kg/min | 6 h | Hypotension, myocardial rupture, headache, sinus tachycardia |
| Poelzl et al. Herz. 2008 [75] | 6 - 12 µg/kg | 0.07 - 0.2 µg/kg/min | 24 h | Not reported |
| Silva-Cardoso et al. Rev Port Cardiol. 2009 [33] | 12 µg/kg | 0.05 - 0.2 µg/kg/min | 24 h | Hypotension, hypokalemia |