J Clin Med Res

Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc

Journal website http://www.jocmr.org

Original Article

Volume 6, Number 3, June 2014, pages 190-196

Value of Twelfth Hour Bilirubin Level in Predicting Significant Hyperbilirubinemia in Preterm Infants

Figure 1. Receiver operating characteristic curve analysis in group 1 (birth weight: 1,000 - 1,499 g) (cutoff: 3.55 mg/dL).

**Table 1.** The Clinical and Laboratory Features of Groups
	Group 1	Group 2	P
CS: Cesarean section; F: female; M: male; NSVD: normal spontaneous vaginal delivery.
Gestation age (weeks) (mean ± SD)	30.1 ± 2.4	32.8 ± 1.4	< 0.001
Birth weight (g) (mean ± SD)	1,213.8 ± 153.5	1,738.6 ± 153.6	< 0.001
Hematocrit (%) (mean ± SD)	50 ± 5.7	52.9 ± 5.3	0.002
Hemoglobin (g/dL) (mean ± SD)	16.9 ± 1.9	17.9 ± 1.9	0.001
Apgar (fifth minute) (mean ± SD)	7.9 ± 0.9	8.2 ± 0.8	0.027
F/M	33/24	44/49	> 0.05
NSVD/CS	8/49	25/68	> 0.05

Table 1. The Clinical and Laboratory Features of Groups

Group 1

Group 2

CS: Cesarean section; F: female; M: male; NSVD: normal spontaneous vaginal delivery.

Gestation age (weeks) (mean ± SD)

30.1 ± 2.4

32.8 ± 1.4

< 0.001

Birth weight (g) (mean ± SD)

1,213.8 ± 153.5

1,738.6 ± 153.6

< 0.001

Hematocrit (%) (mean ± SD)

50 ± 5.7

52.9 ± 5.3

0.002

Hemoglobin (g/dL) (mean ± SD)

16.9 ± 1.9

17.9 ± 1.9

0.001

Apgar (fifth minute) (mean ± SD)

7.9 ± 0.9

8.2 ± 0.8

0.027

F/M

33/24

44/49

> 0.05

NSVD/CS

8/49

25/68

> 0.05

**Table 2.** The Clinical and Laboratory Features of Patients in Group 1
	PT (-) (n = 3)	PT (+) (n = 54)
CS: Cesarean section; F: female; M: male; NSVD: normal spontaneous vaginal delivery; PT: phototherapy.
Gestational age (weeks) (mean ± SD)	32.4 ± 2	30 ± 2.3
Birth weight (g) (mean ± SD)	1,221.7 ± 228.3	1,213.4 ± 151.4
Hematocrit (%) (mean ± SD)	49.6 ± 2.6	50.1 ± 5.9
Hemoglobin (g/dL) (mean ± SD)	17.2 ± 0.6	16.9 ± 2
Apgar (fifth minute) (mean ± SD)	8 (8-8)	8 (8-9)
F/M	2/1	31/23
NSVD/CS	0/3	8/46

Table 2. The Clinical and Laboratory Features of Patients in Group 1

PT (-)
(n = 3)

PT (+)
(n = 54)

CS: Cesarean section; F: female; M: male; NSVD: normal spontaneous vaginal delivery; PT: phototherapy.

Gestational age (weeks) (mean ± SD)

32.4 ± 2

30 ± 2.3

Birth weight (g) (mean ± SD)

1,221.7 ± 228.3

1,213.4 ± 151.4

Hematocrit (%) (mean ± SD)

49.6 ± 2.6

50.1 ± 5.9

Hemoglobin (g/dL) (mean ± SD)

17.2 ± 0.6

16.9 ± 2

Apgar (fifth minute) (mean ± SD)

8 (8-8)

8 (8-9)

F/M

2/1

31/23

NSVD/CS

0/3

8/46

**Table 3.** The Clinical and Laboratory Features of Patients in Group 2
	PT (-) (n = 18)	PT (+) (n = 75)	P
CS: Cesarean section; F: female; M: male; NSVD: normal spontaneous vaginal delivery; PT: phototherapy.
Gestational age (weeks) (mean ± SD)	33.1 ± 1.1	32.7 ± 1.4	0.79
Birth weight (g) (mean ± SD)	1,702.8 ± 150.1	1,747.2 ± 154.2	0.41
Hematocrit (%) (mean ± SD)	52.2 ± 4.1	53.1 ± 5.6	0.86
Hemoglobin (g/dL) (mean ± SD)	17.9 ± 1.5	17.9 ± 2	0.74
Apgar (fifth minute) (mean ± SD)	8 (8-9)	8 (8-9)	0.48
F/M	12/6	32/43	0.06
NSVD/CS	2/16	23/52	0.12

Table 3. The Clinical and Laboratory Features of Patients in Group 2

PT (-)
(n = 18)

PT (+)
(n = 75)

CS: Cesarean section; F: female; M: male; NSVD: normal spontaneous vaginal delivery; PT: phototherapy.

Gestational age (weeks) (mean ± SD)

33.1 ± 1.1

32.7 ± 1.4

0.79

Birth weight (g) (mean ± SD)

1,702.8 ± 150.1

1,747.2 ± 154.2

0.41

Hematocrit (%) (mean ± SD)

52.2 ± 4.1

53.1 ± 5.6

0.86

Hemoglobin (g/dL) (mean ± SD)

17.9 ± 1.5

17.9 ± 2

0.74

Apgar (fifth minute) (mean ± SD)

8 (8-9)

0.48

F/M

12/6

32/43

0.06

NSVD/CS

2/16

23/52

0.12

**Table 4.** Daily Capillary Bilirubin Levels of Both Groups
	n	Bilirubin (mg/dL ± SD)	P
12th hour			0.85
Group1	57	4.5 ± 0.8
Group 2	93	4.7 ± 0.8
24th hour			0.76
Group1	55	6.3 ± 1.4
Group 2	93	6.6 ± 1.4
48th hour			0.016
Group1	35	8.1 ± 1.4
Group 2	87	8.9 ± 1.7
72th hour			< 0.001
Group1	9	7.6 ± 1.3
Group 2	56	9.9 ± 1.8
96th hour			0.02
Group1	7	8.3 ± 1.9
Group 2	34	10.2 ± 1.9
120th hour			0.46
Group1	5	8.2 ± 2.9
Group 2	27	10.0 ± 2.2

Table 4. Daily Capillary Bilirubin Levels of Both Groups

Bilirubin (mg/dL ± SD)

12th hour

0.85

Group1

4.5 ± 0.8

Group 2

4.7 ± 0.8

24th hour

0.76

Group1

6.3 ± 1.4

Group 2

6.6 ± 1.4

48th hour

0.016

Group1

8.1 ± 1.4

Group 2

8.9 ± 1.7

72th hour

< 0.001

Group1

7.6 ± 1.3

Group 2

9.9 ± 1.8

96th hour

0.02

Group1

8.3 ± 1.9

Group 2

10.2 ± 1.9

120th hour

0.46

Group1

8.2 ± 2.9

Group 2

10.0 ± 2.2