Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
Journal website http://www.jocmr.org

Original Article

Volume 5, Number 3, June 2013, pages 168-173

Unintentional Discontinuation of Statins May Increase Mortality After Traumatic Brain Injury in Elderly Patients: A Preliminary Observation

Figures

Figure 1.
Figure 1. Study population flow-chart.
Figure 2.
Figure 2. Outcomes between pre-injury statin continuation and discontinuation groups.

Table

Table 1. Patient Demographics Stratified by In-Hospital Statin Therapy Continuationa
 
CharacteristicsContinued
(n = 46)		Discontinued
(n = 15)		P Value
aNot all data will sum to their respective totals due to missing data. BMI: body mass index; ED: emergency department; GCS: glasgow coma; ISS: injury severity score; BPM: beats per minute; TRISS: trauma and injury severity score; ECG: electrocardiogram.
Age0.75
  55 to 7930 (65%)11 (73%)
  ≥ 8016 (35%)4 (27%)
Male25 (53%)10 (67%)0.40
BMI overweight or obese (≥ 25 kg/m2)29 (67%)4 (29%)0.01
Pre-injury blood thinner use40 (87%)10 (67%)0.12
ED GCS 13 - 1537 (93%)12 (92%)> 0.99
ISS 0 - 1516 (35%)5 (33%)0.92
ED hypotension (< 90 mmHg)1 (2%)0n/a
ED respiratory rate (breaths/min)0.42
  < 10 or > 291 (2%)1 (7%)
  10 to 2944 (98%)13 (93%)
ED tachycardia (> 100 bpm)7 (16%)3 (21%)0.69
TRISS, probability of survival ≥ 80%35 (92%)12 (92%)> 0.99
Charlson comorbidity index0.32
  2 to 37 (15%)4 (27%)
  4 to 630 (64%)10 (67%)
  ≥ 710 (21%)1 (7%)
Mechanism of Injury0.18
  Fall37 (80%)12 (80%)
  Motor vehicle or bicycle8 (17%)1 (7%)
  Other1 (2%)2 (13%)
Blood product transfusion11 (23%)3 (20%)0.72
ED ECG results> 0.99
  Abnormal27 (75%)10 (77%)
  Borderline4 (11%)1 (8%)
  Normal5 (14%)2 (15%)
ED disposition0.70
  Direct admission4 (9%)1 (7%)
  General floor9 (20%)2 (13%)
  Intensive care unit31 (67%)10 (67%)
  Step-down unit2 (4%)2 (13%)