Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
Journal website http://www.jocmr.org

Case Report

Volume 4, Number 6, December 2012, pages 424-428

GAD65 Positive Autoimmune Limbic Encephalitis: A Case Report and Review of Literature

Tables

Table 1. Gultekin Diagnostic Criteria for Limbic Encephalitis
 
Either, Histopathological evidence of limbic encephalitis
OR, Presence of following:
   -Psychiatric symptoms ,short-term memory loss, or temporal lobe seizures suggestive of limbic system involvement
   -Time period between onset of neurological symptoms and cancer diagnosis < 4 years.
   -Exclusion of other etiologies causing limbic encephalopathy : infection, metastases, metabolic causes, stroke and medication side-effects
   -At least one of
      -Inflammatory findings in CSF
      -MRI FLAIR or T2 showing bilateral hyper intensity
      -EEG showing focal temporal lobe changes either epileptic discharges or slowing

 

Table 2. Graus and Saiz Diagnostic Criteria for Limbic Encephalitis
 
-Sub-acute onset (few days to 12 weeks) of short-term memory loss, seizures, confusion and psychiatric symptoms and
-Evidence of limbic system involvement (Radiologic or Neuropathologic) and
-Time period between onset of neurological symptoms and cancer diagnosis < 5 years or development of limbic dysfunction symptomatology in association with a well-defined paraneoplastic antibody (amphiphysin, CV2, Hu, Ma2, Ri) and
-Exclusion of other etiologies explaining above symptoms