Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
Journal website http://www.jocmr.org

Original Article

Volume 8, Number 10, October 2016, pages 737-742


Change of Serum BNP Between Admission and Discharge After Acute Decompensated Heart Failure Is a Better Predictor of 6-Month All-Cause Mortality Than the Single BNP Value Determined at Admission

Figures

Figure 1.
Figure 1. In this plot, the admission serum BNP values are categorized depending on the values that they will assume at the hospital discharge (patients with BNP decrease during hospital stay until discharge compared to patients with BNP rising at hospital discharge). Based on these findings, admission serum BNP was not able to predict the subsequent evolution of BNP levels. Indeed, there were not any differences between basal BNP mean values of patients who will evolve into a BNP decrease at hospital discharge and of those who will show a BNP rise at hospital discharge. ADHF: acute decompensated heart failure; BNP: B-type natriuretic peptide; pg: pictograms.
Figure 2.
Figure 2. The figure shows that patients with BNP increase at the time of discharge had a lower reduction in IVC diameter from admission to discharge (1.58 ± 2.2 mm vs. 6.32 ± 1.82 mm, P = 0.001). In the dot-plot, a continuous line connects the means of the two groups (patients with decreasing BNP and the patients whose BNP shows an increase at discharge).
Figure 3.
Figure 3. Forest plot summarizing results of Cox proportional hazard analysis of predictors of 6-month all-cause mortality in our retrospective study that analyzed 177 patients hospitalized for acute decompensated heart failure and undergone clinical follow-up after their hospital discharge. BNP: B-type natriuretic peptide; NYHA: New York Heart Association.

Tables

Table 1. In Patients Hospitalized for Acute Decompensated Heart Failure, the Odds of Persistent Jugular Venous Distention Is Significantly Higher Among Patients With BNP Rising at Discharge (Yes) Compared to Those Free From This Laboratory Finding (No)
 
JVD
JVD persistenceJVD regressionTotal
For further explanations, please see the text. BNP: B-type natriuretic peptide; JVD: jugular venous distention.
BNP rising at discharge
  Yes322153
  No3688124
  Total68109177
Odds ratio3.7249
95% CI1.8997 - 7.3034
z statistic3.828
Significance levelP = 0.0001

 

Table 2. In Patients Hospitalized for Acute Decompensated Heart Failure, the Odds of Persistent Orthopnea Is Significantly Higher Among Patients With BNP Rising at Discharge (Yes) Compared to Those Free From This Laboratory Finding (No)
 
Orthopnea
Persistence of orthopneaRegression of orthopneaTotal
For further explanations, please see the text. BNP: B-type natriuretic peptide.
BNP rising at discharge
  Yes341953
  No4777124
  Total8196177
Odds ratio2.9317
95% CI1.5025 - 5.7203
z statistic3.154
Significance levelP = 0.0016