Figure 1. Review flowchart.
| Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc |
| Journal website http://www.jocmr.org |
Original Article
Volume 8, Number 4, April 2016, pages 317-324
Efficacy of Stem Cell Therapy in Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis
Figures
Table
| Authors | Year | N | Disease (years) | Follow-up (month) | Outcome | Survival | ALSFRS-R | Adverse events | GRADE |
|---|---|---|---|---|---|---|---|---|---|
| Glass et al [33] | 2012 | 12 | 4.4 | 1.5 | ALSFRS-R; adverse events | Not related | Stable | 12 | 2D |
| Karussis et al [31] | 2010 | 19 | 2.9 | 25 | Adverse events | Not related | Fall light | Fever: 11 | 2D |
| Blanquer et al [37] | 2012 | 11 | 1.8 | 6 | Adverse events/motoneurons | Not related | Stable | Pain and paresthesia: 11 | 2D |
| Prabhakar et al [38] | 2012 | 10 | 1.5 | 24 | Survival | Not related | Decline after 3 months | No | 2D |
| Gamez et al [30] | 2010 | 12 | 2.24 | 47.2 | Survival/tracheo/gastric tube | 48 months | Declining equal to control | Fever, impaired consciousness: 1 | 2D |
| Martinez et al [27] | 2009 | 10 | 2 | 19 | Survival/tracheo/gastric tube | 66 months | Improvement in 1 - 2 months and at 6 months | No | 2C |
| Riley et al [34] | 2014 | 6 | 3.7 | 6 | Adverse events | Not related | Fall | Hemorrhage: 2 | 2D |
| Mazzini et al [28] | 2012 | 10 | 0.7 | 24 | Adverse events/mune | Not related | Fall | Pain: 7 Loss sensitive: 6 | 2D |
| Deda et al [29] | 2009 | 13 | 2.6 | 12 | Adverse events | Not related | Not ascertained | No | 2D |
| Tarella et al [32] | 2010 | 24 | 1 | 12 | Adverse events | Not related | Not ascertained | Prolactinoma: 1 TVPO: 1 | 2C |
| Riley et al [35] | 2012 | 12 | 3.1 | 18 | Adverse events | Not related | Not ascertained | Hemorrhage: 2 reoperated | 2C |
| Mazzini et al [28] | 2012 | 19 | 1.9 | 108 | Adverse events/mortality | 52.5 months | Six patients for 74 months stabilized | No | 2D |
| Sharma et al [36] | 2015 | 37 | Not related | 60 | Survival | Improved 87.76 (10.45) × 57.38 (5.31) | Fall | Minor side effects | 2D |