Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
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Case Report

Volume 7, Number 7, July 2015, pages 566-570

Pleural Epithelioid Hemangioendothelioma: Literature Summary and Novel Case Report

Figures

Figure 1.
Figure 1. Chest radiograph demonstrating complete opacification of the right hemithorax with mild mediastinal shift to the left side.
Figure 2.
Figure 2. CT scan demonstrating pleural thickening, effusion, right lung collapse and left mediastinal shift.
Figure 3.
Figure 3. Histology from VATS guided pleural biopsy. Tumor shows cords, nests and groups of medium or large sized epithelioid cells with inconspicuous nucleoli set in a myxoid stroma. Some cells show mild atypia. Many cells have intracytoplasmic lumina which occasionally contain red blood cells (arrows). Tumor cells are positive for CD31 (insert) and CD34.

Table

Table 1. Summary of Published Cases of Pleural PHE
 
AuthorsAge/genderSymptom at presentationImagingOther sites involvedTreatmentReported survival (months)
Lee et al, 2008 [1]31/FChest painPleural thickening on CTLung, boneAdriamycin, MAID10
Pinet, 1999 [6]50/FNARight pleural effusionAscitesCarboplatin and etoposide18+
Crotty et al, 2000 [7]51 - 71/M
n = 4		Chest pain (3), dyspnea (3), cough, fever (1), weight loss (1)Pleural effusions, nodules and thickeningLung (2), LN, liver and retroperitoneum (1)Unknown1 - 19
(10 on average)
Lazarus, 2011 [8]42/M
+42/M
n = 2		1. Cough, dyspnea, chest pain
2. Fever, cough		1. Right pleural effusion
2. Left pleural effusion		1. Skin
2. No		1. Taxol and bevacizumab
2. Carboplatin, etoposide, and bevacizumab		8
6
Yousem and Hochholzer, 1987 [9]34/MDyspneaBilateral pleural effusionsNoNone3
Lin, 1996 [10]36 - 58/M
n = 6		NAPleural effusion (n = 6)Pericardial effusion n = 1NANA
Al-Sharim et al, 2005 [11]51/MCough, dyspneaLeft pleural effusionSkinINF-alpha24+
Vitorio, 2004 [12]61/MChest painLeft pleural effusion and thickeningNoCisplatin and etoposide3
Saqi, 2007 [13]37/MDyspnea, chest painRight pleural effusionNoNANA
Liu et al, 2010 [14]80/MDyspneaRight-sided effusionNoSurgical, chemotherapy unknown6
Bocchino, 2010 [15]58/FCough, dyspnea, chest painPleural massNoNone3
Andre, 2010 [16]65/FChest painPleural effusionCarboplatin, etoposide6
Kim et al, 2011 [17]46/FCough, chest discomfortRight pleural effusionNoSurgical, carboplatin, etoposide22+
Marquez-Medina, 2011 [18]85/MChest and shoulder pain, fatigue, weight lossPleural effusionNone7
Bansal, 2012 [19]51/FChest pain, weight lossPleural effusion and thickeningNoDoxorubicin4
Yu, 2013 [20]39/FDyspneaPleural mass on CTMyocardial compressionSurgical, carboplatin, etoposide14+
Ha, 2014 [21]71/MCough, dyspnea, fatigueBilateral pleural effusionsPericardial effusion, lungNANA
This case, 201436/FChest painRight whiteoutLungsPaclitaxel6